Effects of thyroid autoimmunity on abdominal obesity and hyperlipidaemia

BACKGROUND: Thyroid autoimmunity has been suggested as a risk factor for atherosclerosis independent of thyroid function in severalstudies. The aim of this study was to investigate whether thyroid autoimmunity had any effect on hyperlipidaemia, obesity and abdominalobesity independent of thyroid fun...

Full description

Saved in:
Bibliographic Details
Published in:Endokrynologia polska 2011, Vol.62 (5), p.421-428
Main Authors: Tamer, Gonca, Mert, Meral, Tamer, Ismet, Mesci, Banu, Kılıc, Damla, Arık, Safiye
Format: Article
Language:English
Subjects:
Abdomen
Atherosclerosis
Cholesterol
Lipids
Obesity
Thyroid gland
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:BACKGROUND: Thyroid autoimmunity has been suggested as a risk factor for atherosclerosis independent of thyroid function in severalstudies. The aim of this study was to investigate whether thyroid autoimmunity had any effect on hyperlipidaemia, obesity and abdominalobesity independent of thyroid function. MATERIAL AND METHODS: 184 premenopausal female patients with Hashimoto’s thyroiditis (HT) and 150 healthy premenopausal femalevolunteers as control group (CG) were included in the study. According to thyroid function status, the patients were divided into threesubgroups: overt hypothyroid patients (ohp), subclinical hypothyroid patients (shp) and euthyroid patients (ep). Body mass index (BMI),waist to hip ratios, waist circumference (WC), and serum lipid levels of all the participants were determined. These parameters of ep werecompared with those of ohp, shp and CG. Relationships among thyroid stimulating hormone (TSH), thyroid autoantibodies and lipidlevels were investigated. RESULTS: There were no significant differences between serum total cholesterol and low density lipoprotein cholesterol (LDL-C) levels of ohpand ep with HT (P = 0.18, P = 0.07 respectively) and LDL-C levels of ep were higher than those of CG (P = 0.03, P = 0.042, respectively).Although TSH levels did not correlate with serum lipid levels, levels of anti-thyroid peroxidase antibody correlated with triglyceride levelsand WCs (r = 0.158; P = 0.013, r = 0.128; P = 0.048 respectively) and negatively correlated with high density lipoprotein cholesterol (HDL-C)levels (r = –0.137; P = 0.031). Levels of anti-thyroglobulin antibody also correlated with triglyceride and nonHDL-C levels (r = 0.208;P = 0.007, r = 0.158; P = 0.043 respectively). CONCLUSION: Thyroid autoimmunity may have some effects on hyperlipidaemia and abdominal obesity independent of thyroid function.(Pol J Endocrinol 2011; 62 (5): 421–428)
ISSN:0423-104X