Circulating vaspin levels and nutritional status and insulin resistance in polycystic ovary syndrome

• Published in: Ginekologia polska 2020-01, Vol.91 (5), p.251-255
• Main Authors: Franik, Grzegorz, Plinta, Ryszard, Madej, Pawel, Owczarek, Aleksander, Bozentowicz-Wikarek, Maria, Chudek, Jerzy, Skrzypulec-Plinta, Violetta, Olszanecka-Glinianowicz, Magdalena
• Format: Article
• Language: English
• Subjects: Insulin resistance; Nutritional status; Plasma; Polycystic ovary syndrome
• ISSN: 0017-0011; 2543-6767
• DOI: 10.5603/GP.2020.0056

OBJECTIVES: The study aimed to assess the associations between circulating vaspin levels and nutritional status (assessedon tha basis of BMI) as well as insulin resistance in PCOS. MATERIAL AND METHODS: Eighty-seven PCOS women, 48 obese and 39 normal weight, were enrolled in the cross-sectionalstudy. Seventy-two Non-PCOS women, 41 obese and 31 normal weight, constituted a control group. Body mass, height andwaist circumference as well as body composition by bioimpedance were measured. In the morning (16h after the last meal)we determined: serum glucose, insulin, androgens, gonadotropin (LH, FSH) and sex hormone-binding globulin (SHBG) aswell as plasma vaspin levels. Standard HOMA-IR formula was used to assess insulin resistance (IR). RESULTS: Plasma vaspin levels were significantly lower in PCOS, both normal weight and obese, than in Non-PCOSgroups. Vaspin levels were similar in normal weight and obese PCOS subgroups. There was no association between plasmavaspin levels and anthropometric parameters in PCOS group. While in Non-PCOS group a negative correlation betweenplasma vaspin levels and body mass (r = –0.26; p < 0.05) was found. We did not observe correlations between plasma vaspinlevels and serum glucose and insulin concentrations as well as HOMA-IR values, however, in multivariable, stepwise backwardregression waist circumference and HOMA-IR values explained 18.0% of plasma vaspin levels variability in the study subjects. CONCLUSIONS: PCOS occurrence is associated with decreased vaspin levels. The influence of nutritional status on vaspin levelobserved in Non-PCOS is abolished in PCOS women, possibly by more severe insulin resistance.