Neurological applications for myocardial MIBG scintigraphy

Signs or symptoms of impaired autonomic regulation of circulationare typically present in patients affected by Parkinson’sdisease (PD), in agreement with the cardiac sympatheticdenervation discovered by Goldstein more than 15 yrs. ago.In particular, the majority of PD patients have a diffuse left ve...

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Bibliographic Details
Published in:Nuclear medicine review. Central & Eastern Europe 2013-01, Vol.16 (1), p.35-41
Main Authors: Cascini, Lucio Giuseppe, Cuccurullo, Vincenzo, Restuccia, Antonio, Tamburrini, Oscar, Rotondo, Antonio, Mansi, Luigi
Format: Article
Language:English
Subjects:
Brain diseases
Denervation
Parkinson's disease
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Summary:Signs or symptoms of impaired autonomic regulation of circulationare typically present in patients affected by Parkinson’sdisease (PD), in agreement with the cardiac sympatheticdenervation discovered by Goldstein more than 15 yrs. ago.In particular, the majority of PD patients have a diffuse left ventricularmyocardial sympathetic denervation, being a normalneurological condition present only in a small number of affectedsubjects. Actually MIBG cardiac imaging is a universallyaccepted method to estimate cardiac sympathetic innervations.This review covers the role of MIBG cardiac imaging in PD as wellas in other parkinsonisms, focusing the attention on technicalproblems and pathophysiological premises for cardiac denervation.In particular new emerging data support the role of MIBG asbiomarker of PD, also before motor symptoms became clinicallyevident. Therefore the timing of cardiac noradrenergic denervationin PD is a key issue and we want to update the analysis ofautonomic cardiovascular abnormalities studied with MIBG inPD and related disorders.
ISSN:1506-9680
1644-4345
DOI:10.5603/NMR.2013.0007