Comparative secondary metabolites profiling and biological activities of aerial, stem and root parts of Salvadora oleoides decne (Salvadoraceae)

In this study, different parts (aerial, stem and root) of Salvadora oleoides Decne were investigated in order to explore their phytochemical composition and biological potential. The bioactive contents were evaluated by conventional spectrophotometric methods. Additionally, the secondary metabolite...

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Bibliographic Details
Published in:Natural product research 2020-12, Vol.34 (23), p.3373-3377
Main Authors: Saleem, Hammad, Ahmad, Irshad, Zengin, Gokhan, Mahomoodally, Fawzi M., Rehman Khan, Kashif-Ur, Ahsan, Hafiz Muhammad, Abidin, Syafiq Asnawi Zainal, Ahemad, Nafees
Format: Article
Language:English
Subjects:
antioxidant
Antioxidants
Antioxidants - chemistry
Antioxidants - pharmacology
Biological activity
Drug Evaluation, Preclinical
enzyme inhibition
Enzyme Inhibitors - chemistry
Enzyme Inhibitors - pharmacology
LC-MS
Lipoxygenase
Metabolites
Methanol - chemistry
phytochemical
Phytochemicals - analysis
Plant Components, Aerial - chemistry
Plant Components, Aerial - metabolism
Plant Extracts - chemistry
Plant Roots - chemistry
Plant Roots - metabolism
Plant Stems - chemistry
Plant Stems - metabolism
Salvadora oleoides
Salvadoraceae - chemistry
Salvadoraceae - metabolism
Scavenging
Secondary Metabolism
Secondary metabolites
Sesquiterpenes - analysis
Sesquiterpenes - metabolism
Spectrophotometry
Stems
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Summary:In this study, different parts (aerial, stem and root) of Salvadora oleoides Decne were investigated in order to explore their phytochemical composition and biological potential. The bioactive contents were evaluated by conventional spectrophotometric methods. Additionally, the secondary metabolite compounds were identified by UHPLC-MS analysis. Biological potential was evaluated by determining antioxidant (DPPH, FRAP, and Phosphomolybdenum) and enzyme inhibitory (butrylcholinesterase and lipoxygenase) effects. Higher total bioactive contents were found in methanolic extracts which tend to correlate with higher radical scavenging and reducing potential of these extracts. LC/MS spectrum revealed the presence of 16 different secondary metabolites belonging to terpene, glucoside and sesquiterpenoid dervivatives. Glucocleomin and emotin A were the main compounds present in all three parts. The strongest butrylcholinesterase and lipoxygenase inhibitory activity was observed for root and stem DCM extracts. Demonstrated biological potential of S. oleoides plant can trace a new road map for developing newly designed bioactive pharmaceuticals.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2018.1564299