Biological and Functional Properties of Wedelolactone in Human Chronic Diseases

Medicinal herbs are well known and studied over the past millennia in most of the developing countries as a rational means of treatment against various diseases and disorders. Wedelolactone (WDL), a major bioactive compound in Eclipta prostrata L (Eclipta alba L), has been reported with potential be...

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Published in:Phyton (Buenos Aires) 2021-01, Vol.90 (1), p.1-15
Main Authors: Vinyagam, Ramachandran, Kumar, Pradeep, Eun Lee, Kyung, Xu, Baojun, Nurul Matin, Muhammad, Gu Kang, Sang
Format: Article
Language:English
Subjects:
Alopecia
Alzheimer's disease
Antioxidants
Bioactive compounds
Biological activity
Biological properties
Chronic illnesses
Developing countries
Diabetes mellitus
Disorders
Herbal medicine
LDCs
Liver cancer
Liver diseases
Medical treatment
Medicinal herbs
Medicinal plants
Neurodegenerative diseases
Oxidants
Oxidizing agents
Pharmacology
Therapeutic applications
Therapeutic targets
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Summary:Medicinal herbs are well known and studied over the past millennia in most of the developing countries as a rational means of treatment against various diseases and disorders. Wedelolactone (WDL), a major bioactive compound in Eclipta prostrata L (Eclipta alba L), has been reported with potential benefits in human health against chronic diseases. However, a comprehensive study on WDL pharmacological benefits in various ailments, to the best of our knowledge, is not yet reported. Thereof, the present review provides the recent therapeutic applications in reference to biological and functional activities against major human chronic diseases, including cardiovascular, cancer, diabetes mellitus, liver disease, Alzheimer’s disease, and androgenetic alopecia. In this study, we collected all the relevant experimental information on WDL from Scientific databases such as PubMed, Web of Science, Science Direct, and Google Scholar. Conclusively, WDL is recognized as a key anti-oxidant with both specific regulator and inhibitor of major drug targetable proteins in human chronic diseases and disorders. Hence, WDL as a novel therapeutic bioactive molecule is advised to explore further for relevant pharmacological activities.
ISSN:1851-5657
0031-9457
1851-5657
DOI:10.32604/phyton.2020.013388