Synthesis of Novel N- (substituted phenyl)-N- (substituted) acetamide Derivatives as a potent Analgesic agent

• Published in: Research journal of pharmacy and technology 2020-11, Vol.13 (11), p.5158-5164
• Main Authors: Verma, Vivek, Yogi, Bhumika, Gupta, Sujeet Kumar
• Format: Article
• Language: English
• Subjects: Acids; Analgesics; Nonsteroidal anti-inflammatory drugs; Pain; Potash; Potassium; Solvents
• ISSN: 0974-3618; 0974-306X
• DOI: 10.5958/0974-360X.2020.00902.6

We have tried to synthesize in the present research a series of novel derivatives of acetamide 2-(substituted phenoxy)-N-(substituted phenyl) acetamide, N-(substituted phenyl)-2-(naphthalen-1-yloxy) acetamide and 2-(otolyloxy)-N-(substituted phenyl) acetamide (5aa-5ec) and assess them for analgesic activity using Eddy hot plate method (Paw licking Model) in Rats (both sexes). In 1st step, we synthesized derivatives of amine and chloroacetyl chloride was separately treated with glacial acetic acid warmed on water bath for 15 min. and added anhydrous Sodium acetate solution in water gives amide derivatives (3a-e). In 2nd step dry acetone as a solvent at 750C for 6 hr final Compound 3a-e converted to 5aa-5ec along the presence of potassium carbonate, the reaction with distinctly modified phenols. The final compound structure was verified by FTIR and 1H NMR. All the values of melting point, FTIR, 1H NMR, Solubility and TLC were observed to be prominent. The pharmacological screening of the compound by Eddy's hot plate in rat Paw Edema Model for analgesic activity synthesized compounds 5ca, 5cb and 5cc was observed to be the effective compounds. Compound 5cb and 5cc was found to be most effective compound compared to the Diclofenac conventional drug. Eddy's hot plate method was utilized to evaluate the test compounds for their in vivo analgesic activity.