Antidiabetic effects of Red Rice Bran Extract (Oryza nivara) and Black Rice Bran Extract (Oryza sativa L. Indica) in Wistar white rat by Glucose Induction Method

Diabetes mellitus is a metabolic syndrome that can cause a lot of complicated disease. Application of natural product is one of alternative treatment that has commonly been applied by the society since then, that is black (Oryza sativa L. Indica) and red (Oryza nivara) ricebran. The aim of this stud...

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Bibliographic Details
Published in:Research journal of pharmacy and technology 2020-11, Vol.13 (11), p.5134-5138
Main Authors: Lolok, Nikeherpianti, Selpirahmawati, Ikawati, Nurlena, Yuliastri, Wa Ode, Isrul, Muhammad
Format: Article
Language:English
Subjects:
Animals
Antidiabetics
Diabetes
Dietary fiber
Disease
Ethanol
Glucose
Metabolic syndrome
Natural products
Variance analysis
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Summary:Diabetes mellitus is a metabolic syndrome that can cause a lot of complicated disease. Application of natural product is one of alternative treatment that has commonly been applied by the society since then, that is black (Oryza sativa L. Indica) and red (Oryza nivara) ricebran. The aim of this study is to understand the effectivity of black rice bran (Oryza sativa L. Indica) extract and redrice bran (Oryza nivara) extract to the deflation of blood glucose in tested animal induced glucose compare to negative control and to understand the effectivity of red rice bran extract and black rice bran extract combination to the deflation of blood glucose in tested animal induced glucose compare to metformin and glibenclamide combination. In this study, samples were extracted by maceration method using ethanol 96%. The assays of antidiabetic effect divided into 3 groups those are negative control, positive control and combination of the extract. Data analysist were conducted using One-way ANOVA and continuing with LSD (Low Significant Difference) test. The result of the test to the mice induced diabetes revealed that combination of the red rice bran extract and black rice bran extract significantly able to reduce blood glucose compare to negative control (p
ISSN:0974-3618
0974-306X
DOI:10.5958/0974-360X.2020.00898.7