Tinospora cordifolia: A Successful Story from Botanical background to Pharmaceutical Product

• Published in: Research journal of pharmacy and technology 2020-11, Vol.13 (11), p.5620-5630
• Main Authors: Gautam, Anamika, Kaur, Harmeet, Kaur, Arvinder, Prashar, Pankaj Kumar, Sood, Ankita, Singh, Sachin Kumar, Gulati, Monica, Pandey, Narendra Kumar, Kumar, Bimlesh
• Format: Article
• Language: English
• Subjects: Ayurvedic medicine; Diabetes; Diuretics; Drug therapy; Herbal medicine; Metabolism; Metabolites; Steroids; Stress; Ulcers
• ISSN: 0974-3618; 0974-306X
• DOI: 10.5958/0974-360X.2020.00980.4

Tinospora Cordifolia (TC) (family: Menispermaceae) is a medicinal plant with multi health benefits. This plant is reported to possess anti-diabetic, anti-periodic, anti-spasmodic, anti-inflammatory, anti-arthritic, anti-oxidant, anti-allergic, anti-stress, anti-leprotic, anti-malarial, hepato-protective, immunomodulatory and anti-neoplastic effects. Each part of this plant and its various species are effective in the treatment of various disorders. AlphaD-glucan of this plant causes activation of immune system through activation of macrophage that occur by TLR6 signaling, NF kappa B translocation and cytokine production. Its extract is antagonizing the effect of Histamine, 5-HT, bradykinin, PGEi in smooth muscle of rat. Scientific reports stablished that, LD50 value was higher than 1 g/kg in case of oral administration in experimental animal apart from that no abnormalities were detected in liver and renal function of rats received 100mg/kg for 12 weeks. 3g/kg of its administration did not show any adverse effects or animal death in Wistar albino rats undergone acute toxicity studies. TC reported safe in a phase I study. Clinically it was reported that its aqueous extract decreases the toxic effects of alcohol and help to modulate testosterone and cholesterol biosynthesis. Hence present review focus on preclinical and clinical importance of TC and its bioactive compounds.