Tinospora cordifolia: A Successful Story from Botanical background to Pharmaceutical Product

Tinospora Cordifolia (TC) (family: Menispermaceae) is a medicinal plant with multi health benefits. This plant is reported to possess anti-diabetic, anti-periodic, anti-spasmodic, anti-inflammatory, anti-arthritic, anti-oxidant, anti-allergic, anti-stress, anti-leprotic, anti-malarial, hepato-protec...

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Published in:Research journal of pharmacy and technology 2020-11, Vol.13 (11), p.5620-5630
Main Authors: Gautam, Anamika, Kaur, Harmeet, Kaur, Arvinder, Prashar, Pankaj Kumar, Sood, Ankita, Singh, Sachin Kumar, Gulati, Monica, Pandey, Narendra Kumar, Kumar, Bimlesh
Format: Article
Language:English
Subjects:
Ayurvedic medicine
Diabetes
Diuretics
Drug therapy
Herbal medicine
Metabolism
Metabolites
Steroids
Stress
Ulcers
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container_issue 11
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container_title Research journal of pharmacy and technology
container_volume 13
creator Gautam, Anamika
Kaur, Harmeet
Kaur, Arvinder
Prashar, Pankaj Kumar
Sood, Ankita
Singh, Sachin Kumar
Gulati, Monica
Pandey, Narendra Kumar
Kumar, Bimlesh
description Tinospora Cordifolia (TC) (family: Menispermaceae) is a medicinal plant with multi health benefits. This plant is reported to possess anti-diabetic, anti-periodic, anti-spasmodic, anti-inflammatory, anti-arthritic, anti-oxidant, anti-allergic, anti-stress, anti-leprotic, anti-malarial, hepato-protective, immunomodulatory and anti-neoplastic effects. Each part of this plant and its various species are effective in the treatment of various disorders. AlphaD-glucan of this plant causes activation of immune system through activation of macrophage that occur by TLR6 signaling, NF kappa B translocation and cytokine production. Its extract is antagonizing the effect of Histamine, 5-HT, bradykinin, PGEi in smooth muscle of rat. Scientific reports stablished that, LD50 value was higher than 1 g/kg in case of oral administration in experimental animal apart from that no abnormalities were detected in liver and renal function of rats received 100mg/kg for 12 weeks. 3g/kg of its administration did not show any adverse effects or animal death in Wistar albino rats undergone acute toxicity studies. TC reported safe in a phase I study. Clinically it was reported that its aqueous extract decreases the toxic effects of alcohol and help to modulate testosterone and cholesterol biosynthesis. Hence present review focus on preclinical and clinical importance of TC and its bioactive compounds.
doi_str_mv 10.5958/0974-360X.2020.00980.4
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subjects Ayurvedic medicine
Diabetes
Diuretics
Drug therapy
Herbal medicine
Metabolism
Metabolites
Steroids
Stress
Ulcers
title Tinospora cordifolia: A Successful Story from Botanical background to Pharmaceutical Product
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