A new role for cytidine deaminase in the control of DNA replication and genomic stability

DNA spreading analysis and nucleotide incorporation studies demonstrate that CDA increases DNA synthesis efficiency during S and late G2/M phase of the cell cycle following genotoxic stress. Results obtained from Capan-1 cells depleted for CDA (shCDA) and from MIA PaCa-2 +CDA (lentiCDA).Figure 3Mode...

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Published in:Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2020-11, Vol.20, p.S41-S42
Main Authors: Lumeau, A., Frances, A., Madrid-Mencia, M., Ribeyre, C., Pillaire, M., Bergoglio, V., Torrisani, J., Lutzmann, M., Buscail, L., Hoffmann, J., Cordelier, P.
Format: Article
Language:English
Subjects:
Cell cycle
Cytidine deaminase
Deoxyribonucleic acid
DNA
DNA biosynthesis
Genomes
Genomic instability
Genotoxicity
Mutation
Mutation rates
Pancreas
Pancreatic cancer
Replication
Tumors
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Summary:DNA spreading analysis and nucleotide incorporation studies demonstrate that CDA increases DNA synthesis efficiency during S and late G2/M phase of the cell cycle following genotoxic stress. Results obtained from Capan-1 cells depleted for CDA (shCDA) and from MIA PaCa-2 +CDA (lentiCDA).Figure 3Model for the new role of cytidine deaminase in the control of DNA replication stress and genomic stability.Figure 4CDA expression is positively correlated with genetic instability and mutation rate in pancreatic tumors. Differential expression analysis of TCGA data determines pancreatic tumors with high and low CDA expression.Figure 4Figure 5Hypothetic model : the new role for CDA as a gatekeeper to maintain thresholds of replication stress compatible with cancer development and resistance to treatment.Figure 5 The authors do not declare any conflict of interest
ISSN:1424-3903
1424-3911
DOI:10.1016/j.pan.2020.07.054