A small-sized benzothiazole-indolium fluorescent probe: the study of interaction specificity targeting c-MYC promoter G-quadruplex structures and live cell imaging

A small-sized c-MYC promoter G-quadruplex selective fluorescent BZT-Indolium binding ligand was demonstrated for the first time as a highly target-specific and photostable probe for in vitro staining and live cell imaging and it was found to be able to inhibit the amplification of the c-MYC G-rich s...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2020-12, Vol.56 (95), p.1516-1519
Main Authors: Zheng, Bo-Xin, She, Meng-Ting, Long, Wei, Xu, Yong-Yu, Zhang, Yi-Han, Huang, Xuan-He, Liu, Wenjie, Hou, Jin-Qiang, Wong, Wing-Leung, Lu, Yu-Jing
Format: Article
Language:English
Subjects:
Fluorescent indicators
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Summary:A small-sized c-MYC promoter G-quadruplex selective fluorescent BZT-Indolium binding ligand was demonstrated for the first time as a highly target-specific and photostable probe for in vitro staining and live cell imaging and it was found to be able to inhibit the amplification of the c-MYC G-rich sequence (G-quadruplex) and down-regulate oncogene c-MYC expression in human cancer cells (HeLa). A small-sized and target-specific fluorescent probe reveals the presence of c-MYC DNA G4-structures in cells and shows anticancer activity.
ISSN:1359-7345
1364-548X
DOI:10.1039/d0cc06525k