Design and characterization of pH stimuli‐responsive nanofiber drug delivery system: The promising targeted carriers for tumor therapy

New carrier platforms have been designed for an electrospun pyridinium calixarene nanofiber for controlled drug delivery. First, 5,11,17,23‐tetra‐tert‐butyl‐25,27‐bis(3‐aminomethyl‐pyridineamido)‐26,28‐dihydroxycalix[4]arene (3‐AMP) scaffold was produced by electrospinning. AMP scaffold was modified...

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Bibliographic Details
Published in:Journal of applied polymer science 2021-03, Vol.138 (11), p.n/a
Main Authors: Ozcan, Fatih, Cagil, Esra Maltas
Format: Article
Language:English
Subjects:
Atomic force microscopy
biomedical applications
Calixarenes
Doxorubicin
Drug delivery systems
Electron microscopes
electrospinning
Emission analysis
Fluorescence
Folic acid
Fourier transforms
Glutathione
Materials science
Microscopy
Nanofibers
Polymers
Scaffolds
Serum albumin
stimuli‐sensitive polymers
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Summary:New carrier platforms have been designed for an electrospun pyridinium calixarene nanofiber for controlled drug delivery. First, 5,11,17,23‐tetra‐tert‐butyl‐25,27‐bis(3‐aminomethyl‐pyridineamido)‐26,28‐dihydroxycalix[4]arene (3‐AMP) scaffold was produced by electrospinning. AMP scaffold was modified by human serum albumin (HSA), folic acid (FA), and glutathione (GSH). Doxorubicin (DOX) was loaded to surfaces of the AMP, AMP‐HSA, AMP‐HSA‐FA, and AMP‐HSA‐GSH nanofibers by using DOX solution in different buffers with, 2.2, 4.0, 6.0, and 7.4 pH. The release studies DOX from four different nanofibers was also done in a various amount microenviroments by changing pH values. The loading and release amount of DOX was estimated from the calibration curve drawn at 480 and 560 nm of excitation and emission wavelengths by using a fluorescence spectrophotometer. The loading studies were confirmed by Fourier transforms infrared, atomic force microscopy, transmission electron microscopy, scanning electron microscope, and energy‐dispersive X‐ray (EDX) analysis.
ISSN:0021-8995
1097-4628
DOI:10.1002/app.50041