Evaluation of the effect of Silybum marianum extract on menopausal symptoms: A randomized, double‐blind placebo‐controlled trial

The tendency to use herbs to manage menopausal symptoms has increased in recent years. The purpose of this study was to evaluate the effect of Silybum marianum (L.) compared with placebo in women with hot flashes. Eighty women were randomly allocated into two equal groups (S. marianum extract [400 m...

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Bibliographic Details
Published in:Phytotherapy research 2020-12, Vol.34 (12), p.3359-3366
Main Authors: Saberi, Zohreh, Gorji, Narjes, Memariani, Zahra, Moeini, Reihaneh, Shirafkan, Hoda, Amiri, Mania
Format: Article
Language:English
Subjects:
Adult
Double-Blind Method
Double-blind studies
Evaluation
Female
Herbal medicine
Hot flash
hot flashes
Hot Flashes - drug therapy
Humans
Menopause
Menopause - drug effects
Middle Aged
Milk thistle
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Plants, Medicinal - chemistry
Silybum marianum
Silybum marianum - chemistry
Treatment Outcome
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Summary:The tendency to use herbs to manage menopausal symptoms has increased in recent years. The purpose of this study was to evaluate the effect of Silybum marianum (L.) compared with placebo in women with hot flashes. Eighty women were randomly allocated into two equal groups (S. marianum extract [400 mg/d] or placebo capsules). Hot flashes frequency and severity were evaluated in 12 weeks with the Greene Climacteric Scale (GCS) and the Hot Flash Related Daily Interference Scale (HFRDIS). The data were analyzed in SPSS software using t‐test, Mann–Whitney, chi‐square test and repeated measure analysis. Hot flashes frequency and severity decreased from 4.32 ± 0.20/day to 1.31 ± 0.15/day and from 5.25 ± 0.22 to 1.62 ± 0.08, respectively, during the study in test group (p
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.6789