Nanodiamond as efficient peroxidase mimic against periodontal bacterial infection

Enzyme mimics have been developed as a new generation of antibiotics with broad-spectrum antibacterial properties to combat bacteria. In this study, a peroxidase mimic was constructed from nanodiamonds (NDs) to treat periodontal pathogen-induced infections with decreasing damage of periodontal tissu...

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Bibliographic Details
Published in:Carbon (New York) 2020-11, Vol.169, p.370-381
Main Authors: Fang, Jiao, Wang, Huan, Bao, Xingfu, Ni, Yuxin, Teng, Yun, Liu, Junsong, Sun, Xiaolin, Sun, Yue, Li, Hongdong, Zhou, Yanmin
Format: Article
Language:English
Subjects:
Antibacterial
Antibiotics
Bacteria
Bacterial infections
Biocompatibility
Cell membranes
Chemotherapy
Diamonds
Hydrogen peroxide
Nanodiamond
Nanostructure
Periodontal pathogens
Peroxidase
Peroxidase mimic
Wound healing
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Summary:Enzyme mimics have been developed as a new generation of antibiotics with broad-spectrum antibacterial properties to combat bacteria. In this study, a peroxidase mimic was constructed from nanodiamonds (NDs) to treat periodontal pathogen-induced infections with decreasing damage of periodontal tissues by traditional drug therapy. The oxygenated nanodiamonds (O-NDs) have excellent enzymatic activity over a broad pH range, and locally activated free-radical generations from low concentration of hydrogen peroxide, presenting a significantly enhancement in bacterial cell membrane disruptions and breaking down biofilms. In the presence of trace non-toxic hydrogen peroxide, topical rinse treatments with O-NDs restrain the development of bacterial infection in vivo, thus preventing and ameliorating the course of periodontal inflammation in a rodent model. More importantly, the enzymatic activity of O-NDs can accelerate the wound healing around sites of periodontal infection in time. The platform of nanodiamond-based enzyme mimic is built having high performance antibiotic-free periodontal antibacterial therapy, and can be extended to other fields of medical applications. [Display omitted]
ISSN:0008-6223
1873-3891
DOI:10.1016/j.carbon.2020.07.055