Nanodiamond as efficient peroxidase mimic against periodontal bacterial infection

• Published in: Carbon (New York) 2020-11, Vol.169, p.370-381
• Main Authors: Fang, Jiao, Wang, Huan, Bao, Xingfu, Ni, Yuxin, Teng, Yun, Liu, Junsong, Sun, Xiaolin, Sun, Yue, Li, Hongdong, Zhou, Yanmin
• Format: Article
• Language: English
• Subjects: Antibacterial; Antibiotics; Bacteria; Bacterial infections; Biocompatibility; Cell membranes; Chemotherapy; Diamonds; Hydrogen peroxide; Nanodiamond; Nanostructure; Periodontal pathogens; Peroxidase; Peroxidase mimic; Wound healing
• ISSN: 0008-6223; 1873-3891
• DOI: 10.1016/j.carbon.2020.07.055

Enzyme mimics have been developed as a new generation of antibiotics with broad-spectrum antibacterial properties to combat bacteria. In this study, a peroxidase mimic was constructed from nanodiamonds (NDs) to treat periodontal pathogen-induced infections with decreasing damage of periodontal tissues by traditional drug therapy. The oxygenated nanodiamonds (O-NDs) have excellent enzymatic activity over a broad pH range, and locally activated free-radical generations from low concentration of hydrogen peroxide, presenting a significantly enhancement in bacterial cell membrane disruptions and breaking down biofilms. In the presence of trace non-toxic hydrogen peroxide, topical rinse treatments with O-NDs restrain the development of bacterial infection in vivo, thus preventing and ameliorating the course of periodontal inflammation in a rodent model. More importantly, the enzymatic activity of O-NDs can accelerate the wound healing around sites of periodontal infection in time. The platform of nanodiamond-based enzyme mimic is built having high performance antibiotic-free periodontal antibacterial therapy, and can be extended to other fields of medical applications. [Display omitted]