Plant natural products with anti-thyroid cancer activity

Thyroid cancer is the most frequent endocrine malignancy, with more than 500,000 cases per year worldwide. Differentiated thyroid cancers are the most common forms with best prognosis, while poorly/undifferentiated ones are rare (2% of all thyroid cancer), aggressive, frequently metastasize and have...

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Bibliographic Details
Published in:Fitoterapia 2020-10, Vol.146, p.104640-14, Article 104640
Main Authors: Sharifi-Rad, Javad, Rajabi, Sadegh, Martorell, Miquel, López, Maria Dolores, Toro, María Trinidad, Barollo, Susi, Armanini, Decio, Fokou, Patrick Valere Tsouh, Zagotto, Giuseppe, Ribaudo, Giovanni, Pezzani, Raffaele
Format: Article
Language:English
Subjects:
Anaplastic thyroid cancer
Biological activity
Cancer
Curcumin
Follicular thyroid cancer
Glucosinolates
Isoflavones
Malignancy
Medullary thyroid cancer
Metabolites
Metastases
Natural products
Papillary thyroid cancer
Phytochemicals
Phytotherapeutics
Phytotherapy
Plant extracts
Plant natural products
Prognosis
Resveratrol
Thyroid
Thyroid cancer
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Summary:Thyroid cancer is the most frequent endocrine malignancy, with more than 500,000 cases per year worldwide. Differentiated thyroid cancers are the most common forms with best prognosis, while poorly/undifferentiated ones are rare (2% of all thyroid cancer), aggressive, frequently metastasize and have a worse prognosis. For aggressive, metastatic and advanced thyroid cancer novel antitumor molecules are urgently needed and phytochemical products can be a rational and extensive source, since secondary plant metabolites can guarantee the necessary biochemical variability for therapeutic purpose. Among bioactive molecules that present biological activity on thyroid cancer, resveratrol, curcumin, isoflavones, glucosinolates are the most common and used in experimental model. Most of them have been studied both in vitro and in vivo on this cancer, but rarely in clinical trial. This review summarizes phytochemicals, phytotherapeutics and plant derived compounds used in thyroid cancer. [Display omitted] •Thyroid cancer (TC) is the most common endocrine malignancy.•Undifferentiated TC is rare, aggressive, with poor prognosis.•No review summarizes the use phytochemicals in TC.
ISSN:0367-326X
1873-6971
DOI:10.1016/j.fitote.2020.104640