Convenient synthesis of novel pyrimidobenzothiazepines

Reaction of 4,6‐dichloropyrimidine‐5‐carbaldehyde with amines in chloroform gave 4‐(substitutedamino)‐6‐chloro‐pyrimidine‐5‐carbaldehydes derivatives at low temperature. Treatment of the latter products with 2‐aminobenzenethiol in alkaline benzene and then in boiling acetonitrile gave a novel group...

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Bibliographic Details
Published in:Journal of heterocyclic chemistry 2020-12, Vol.57 (12), p.4380-4384
Main Authors: Nikpour, Mohsen, Hasanzadeh, Neda
Format: Article
Language:English
Subjects:
Acetonitrile
Amines
Benzene
Benzodiazepines
Chemical synthesis
Chloroform
Derivatives
Low temperature
Mass spectra
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Summary:Reaction of 4,6‐dichloropyrimidine‐5‐carbaldehyde with amines in chloroform gave 4‐(substitutedamino)‐6‐chloro‐pyrimidine‐5‐carbaldehydes derivatives at low temperature. Treatment of the latter products with 2‐aminobenzenethiol in alkaline benzene and then in boiling acetonitrile gave a novel group of 11H‐pyrimido[4,5‐b][1,5]benzodiazepine derivatives. Structures of the products confirmed by 1HNMR, IR, and mass spectra.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.4141