Two coordination polymers: treatment activity on the bacterial infection in the hemodialysis patients via inhibiting Staphylococcus aureus survival

The reaction of 5,5′-(1,3,6,8-tetraoxobenzo[lmn][3,8]phenanthrolin-2-7-diyl)bis-1,3-benzenedicarboxylic acid (H4L) with Zn(II)/Co(II) in the presence of different N-donor co-ligands yielded two transition metal coordination polymers (CPs), {[Co(H2L)(4,4′-bibp)]·H2O}n (1) and {[ZnL0.5(1,4-bimb)0.5(H2...

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Bibliographic Details
Published in:Journal of coordination chemistry 2020-11, Vol.73 (24), p.3332-3343
Main Authors: Heng-Yuan, Zhang, Li-Jing, Yao, Chen, Xing, Ji-Yi, Huang
Format: Article
Language:English
Subjects:
Bacteria
Bacterial infections
Benzene
Catheters
Cobalt
Coordination polymers
Cytokines
Gene expression
Hemodialysis
Infections
Survival
Transition metals
Zinc
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Summary:The reaction of 5,5′-(1,3,6,8-tetraoxobenzo[lmn][3,8]phenanthrolin-2-7-diyl)bis-1,3-benzenedicarboxylic acid (H4L) with Zn(II)/Co(II) in the presence of different N-donor co-ligands yielded two transition metal coordination polymers (CPs), {[Co(H2L)(4,4′-bibp)]·H2O}n (1) and {[ZnL0.5(1,4-bimb)0.5(H2O)]·EtOH}n (2), by using 1,4-bis(imidazol-1-ylmethyl)benzene (1,4-bimb)/4,4′-bis(benzoimidazo-1-yl)biphenyl (4,4′-bbib) as the additive. Their treatment effect on the bacterial infection in the hemodialysis patients was then evaluated. The catheter infection animal model was constructed first. The bacterial numbers on the catheter were counted after compound treatment. Then, the survival rate of the Staphylococcus aureus (SA) was assessed in vitro after treatment with 1 or 2. The survival genes relative expression level on the SA was detected through the real time RT-PCR method. Finally, the inflammatory cytokines released into plasma in the process of infection was measured through the ELISA test kit.
ISSN:0095-8972
1029-0389
DOI:10.1080/00958972.2020.1846187