Dose-dependent effect of the pulsed Nd:YAG laser in the treatment of crushed sciatic nerve in Wister rats: an experimental model

The objective of the study was to investigate the efficacy of three energy densities 4, 10, and 50 J/cm 2 of pulsed Nd:YAG laser for the treatment of crushed sciatic nerve in Wister rats by evaluating changes in the sciatic functional index and the electrophysiology.A total of 180 Wistar rats were i...

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Published in:Lasers in medical science 2020-12, Vol.35 (9), p.1989-1998
Main Authors: Alayat, Mohamed Salaheldien Mohamed, Basalamah, Mohammad Abubakar, Elbarrany, Wagih Gamal Eldin Abd-Elghany, El-Sawy, Naser Ahmed Mahmoud, Abdel-Kafy, Ehab Mohamed, El-Fiky, Amir Abdel-Raouf
Format: Article
Language:English
Subjects:
Action potential
Action Potentials - radiation effects
Animal models
Animals
Crushing
Dentistry
Disease Models, Animal
Dose-Response Relationship, Radiation
Electrophysiology
Energy
Lasers
Lasers, Solid-State - therapeutic use
Male
Medicine
Medicine & Public Health
Neodymium lasers
Nerve conduction
Nerve Crush
Nerve Regeneration - physiology
Neural Conduction - radiation effects
Optical Devices
Optics
Original Article
Photonics
Quantum Optics
Rats, Wistar
Sciatic nerve
Sciatic Nerve - injuries
Sciatic Nerve - physiopathology
Sciatic Nerve - radiation effects
Semiconductor lasers
Variance analysis
YAG lasers
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Summary:The objective of the study was to investigate the efficacy of three energy densities 4, 10, and 50 J/cm 2 of pulsed Nd:YAG laser for the treatment of crushed sciatic nerve in Wister rats by evaluating changes in the sciatic functional index and the electrophysiology.A total of 180 Wistar rats were involved in the study. Rats were randomly assigned to five groups. Rats were subjected to the sciatic nerve crushing. Control negative (CONT-ve), which received no crushing; control positive (CONT+ve), which received crushing with no laser; and HILT-4, HILT-10, and HILT-50 groups, which received pulsed Nd:YAG laser (10 Hz, 360 mJ/cm 2 ) with energy densities 4, 10, and 50 J/cm 2 , respectively. The SFI, the amilitude of compound motor action potential (CMAP) and sciatic motor nerve conduction velocity (MNCV) were measured before and after seven, 14, and 21 days after crushing. For the SFI and electrophysiological analysis, repeated measures ANOVA is used, followed by Bonferroni’s repeated-measures test. Statistical significance was set at p  
ISSN:0268-8921
1435-604X
DOI:10.1007/s10103-020-02999-z