Designed poly(ethylene glycol) conjugate-erbium-doped magnetic nanoparticle hybrid carrier: enhanced activity of anticancer drug

Magnetic drug carriers are aimed at transporting the loaded drugs to the target site with the application of an external field. To realize this, a clever design of magnetic nanoparticles and their surface modification have to be achieved. Herein, we report the synthesis of ErFeO 3 nanoparticles and...

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Bibliographic Details
Published in:Journal of materials science 2021-02, Vol.56 (5), p.3925-3934
Main Authors: Kaliyamoorthi, Kiruthiga, Sumohan Pillai, Archana, Alexander, Aleyamma, Ramasamy, Sivaraj, Arivarasu, Anitha, Enoch, Israel V. M. V.
Format: Article
Language:English
Subjects:
Anticancer properties
Cancer
Characterization and Evaluation of Materials
Chemistry and Materials Science
Classical Mechanics
Coatings
Conjugates
Crystallography and Scattering Methods
Cyclodextrins
Design modifications
Diffraction
Drug carriers
Drug delivery systems
Drugs
Erbium
Ferromagnetism
Folic acid
Free form
Grain size
Magnetic properties
Materials for Life Sciences
Materials Science
Nanoparticles
Polyethylene glycol
Polymer coatings
Polymer Sciences
Solid Mechanics
Vehicles
X ray photoelectron spectroscopy
X-rays
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Summary:Magnetic drug carriers are aimed at transporting the loaded drugs to the target site with the application of an external field. To realize this, a clever design of magnetic nanoparticles and their surface modification have to be achieved. Herein, we report the synthesis of ErFeO 3 nanoparticles and their magnetic characteristics. In addition, we report a β -cyclodextrin-polyethylene glycol-folate conjugate and utilize it for coating the magnetic nanoparticles. The crystallinity and grain size of the nanoparticles are characterized using X-ray diffraction. The elemental composition of the nanoparticles and their orbital states are determined using XPS spectroscopy. The polymer-coated nanoparticles are soft ferromagnetic. The anticancer drug, camptothecin, is loaded on the polymer-coated nanoparticles with a loading percentage of about 88%. The efficacy of camptothecin gets enhanced when loaded on the magnetic nanocarrier and released in a sustained manner. Compared to the free form, the drug loaded on the nanocarrier shows an enhanced anticancer activity. Graphical abstract
ISSN:0022-2461
1573-4803
DOI:10.1007/s10853-020-05466-w