Renoprotective Effects of Di- and Tri-peptides Containing Proline, Glycine and Leucine in Diabetes Model of Adult Mice: Enzymology and Histopathology

The small peptides, as multifunctional biomolecules, can affect some organs and metabolic disorders. The purpose of this experiment was to investigate the effects of some small peptides on the renal enzymes and histopathology in mice exposed to diabetes. Solid phase peptide synthesis method was used...

Full description

Saved in:
Bibliographic Details
Published in:International journal of peptide research and therapeutics 2020-12, Vol.26 (4), p.2345-2354
Main Authors: Vahdatpour, Tohid, Valizadeh, Hadi, Mirzakhani, Navideh, Mesgari-Abbasi, Mehran
Format: Article
Language:English
Subjects:
Alanine
Alanine transaminase
Alkaline phosphatase
Animal Anatomy
Antioxidants
Apoptosis
Aspartate aminotransferase
Biochemistry
Biomedical and Life Sciences
Carnosine
Catalase
Deoxyribonucleic acid
Diabetes
Diabetes mellitus
DNA
DNA damage
Enzymes
Glutathione peroxidase
Histology
Histopathology
Kidneys
Leucine
Life Sciences
Malondialdehyde
Metabolic disorders
Molecular Medicine
Morphology
Peptide synthesis
Peptides
Pharmaceutical Sciences/Technology
Pharmacology/Toxicology
Polymer Sciences
Proline
Streptozocin
Superoxide dismutase
Thiobarbituric acid
Transaminase
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The small peptides, as multifunctional biomolecules, can affect some organs and metabolic disorders. The purpose of this experiment was to investigate the effects of some small peptides on the renal enzymes and histopathology in mice exposed to diabetes. Solid phase peptide synthesis method was used to synthesis di- and tri-peptides. Diabetes was induced in mice by multiple injection of low doses of streptozotocin. The effects of the di- and tri-peptides on renal aspartate aminotransferase, alanine transaminase, alkaline phosphatase, superoxide dismutase (SOD), glutathione peroxidase, total antioxidant (TAC), and catalase activities were evaluated by enzymatic biochemical methods and malondialdehyde (MDA) by thiobarbituric acid method. Hematoxylin and eosin and TUNEL stainings performed for assessing histopathology and apoptosis of the mice kidney. Hannaneh (Leu–Gly) and carnosine (Ala–His) exhibited suppression effects on the blood glucose elevation and the severity of the renal alterations in diabetic mice. They showed a decreasing effect on diabetes-induced DNA damage (P 
ISSN:1573-3149
1573-3904
DOI:10.1007/s10989-020-10024-8