Pharmacokinetics, bioavailability and tissue residues of doxycycline in Japanese quails (Coturnix coturnix japonica) after oral administration

This study aimed to determine the bioavailability, tissue residue and withdrawal time of doxycycline after oral administration in Japanese quails (Coturnix coturnix japonica). Japanese quails received doxycycline at 20 mg/kg dose following either single intravenous or oral administration, or 5-day o...

Full description

Saved in:
Bibliographic Details
Published in:Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment Chemistry, analysis, control, exposure & risk assessment, 2020-12, Vol.37 (12), p.2082-2092
Main Authors: Tekeli, Ibrahim Ozan, Turk, Erdinc, Durna Corum, Duygu, Corum, Orhan, Kirgiz, Fatma Ceren, Uney, Kamil
Format: Article
Language:English
Subjects:
Antibiotics
Bioavailability
Coturnix coturnix japonica
Doxycycline
High performance liquid chromatography
Intravenous administration
Kidneys
Liquid chromatography
Liver
Muscles
Oral administration
Pharmacokinetics
quail
residue
Residues
Skin
Tissues
withdrawal time
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study aimed to determine the bioavailability, tissue residue and withdrawal time of doxycycline after oral administration in Japanese quails (Coturnix coturnix japonica). Japanese quails received doxycycline at 20 mg/kg dose following either single intravenous or oral administration, or 5-day oral administration. Doxycycline concentrations in plasma, liver, kidney, muscle, and skin + fat were determined using high-performance liquid chromatography-ultraviolet. The Withdrawal Time v1.4 software was used to calculate withdrawal times. Following single oral administration, terminal elimination half-life, area under the concentration-time curve from 0 to infinitive time, peak plasma concentration (C max ) and time to reach C max were 10.98 h, 215.84 (h*µg)/mL, 15.33 μg/mL, and 2 h, respectively. The oral bioavailability was 25.84% in quails. In this study, the mean doxycycline concentration was below the maximum residue limit (MRL) at day 4 in skin + fat (0.120 µg/g), and at day 5 in kidney (0.41 µg/g), liver (0.26 µg/g), and muscle (
ISSN:1944-0049
1944-0057
DOI:10.1080/19440049.2020.1825827