Estimation of Absolute Bioavailability of the Chemical Substance of the Anti-Smallpox Preparation NIOCH-14 in Mice

We compared absolute bioavailability of the chemical substance of the anti-smallpox preparation NIOCH-14 and chemical compound ST-246 active against orthopoxviruses after oral administration to mice in doses of 10 and 50 μg/g and intravenous administration to mice in a dose of 2 μg/g body weight. Th...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2020-12, Vol.170 (2), p.207-210
Main Authors: Mazurkov, O. Yu, Shishkina, L. N., Bormotov, N. I., Skarnovich, M. O., Serova, O. A., Mazurkova, N. A., Chernonosov, A. A., Tikhonov, A. Ya, Selivanov, B. A.
Format: Article
Language:English
Subjects:
Bioavailability
Biomedical and Life Sciences
Biomedicine
Body weight
Cell Biology
Health aspects
Internal Medicine
Intravenous administration
Laboratory Medicine
Oral administration
Pathology
Smallpox
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Summary:We compared absolute bioavailability of the chemical substance of the anti-smallpox preparation NIOCH-14 and chemical compound ST-246 active against orthopoxviruses after oral administration to mice in doses of 10 and 50 μg/g and intravenous administration to mice in a dose of 2 μg/g body weight. The absolute bioavailability of NIOCH-14 is comparable with the absolute bioavailability of ST-246.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-020-05034-x