Revisiting biomolecular NMR spectroscopy for promoting small-molecule drug discovery

Recently, there has been increasing interest in new modalities such as therapeutic antibodies and gene therapy at a number of pharmaceutical companies. Moreover, in small-molecule drug discovery at such companies, efforts have focused on hard-to-drug targets such as inhibiting protein–protein intera...

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Bibliographic Details
Published in:Journal of biomolecular NMR 2020-11, Vol.74 (10-11), p.501-508
Main Authors: Hanzawa, Hiroyuki, Shimada, Takashi, Takahashi, Mizuki, Takahashi, Hideo
Format: Article
Language:English
Subjects:
Antibodies
Biochemistry
Biological and Medical Physics
Biophysics
Drug development
Drug discovery
Gene therapy
Information processing
Magnetic resonance spectroscopy
NMR
NMR spectroscopy
Nuclear magnetic resonance
Perspective
Pharmaceutical industry
Physics
Physics and Astronomy
Protein interaction
Proteins
Spectrometers
Spectroscopy
Spectroscopy/Spectrometry
Spectrum analysis
Therapeutic targets
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Summary:Recently, there has been increasing interest in new modalities such as therapeutic antibodies and gene therapy at a number of pharmaceutical companies. Moreover, in small-molecule drug discovery at such companies, efforts have focused on hard-to-drug targets such as inhibiting protein–protein interactions. Biomolecular NMR spectroscopy has been used in drug discovery in a variety of ways, such as for the reliable detection of binding and providing three-dimensional structural information for structure-based drug design. The advantages of using NMR spectroscopy have been known for decades (Jahnke in J Biomol NMR 39:87–90, (2007); Gossert and Jahnke in Prog Nucl Magn Reson Spectrosc 97:82–125, (2016)). For tackling hard-to-drug targets and increasing the success in discovering drug molecules, in-depth analysis of drug–target protein interactions performed by biophysical methods will be more and more essential. Here, we review the advantages of NMR spectroscopy as a key technology of biophysical methods and also discuss issues such as using cutting-edge NMR spectrometers and increasing the demand of utilizing conformational dynamics information for promoting small-molecule drug discovery.
ISSN:0925-2738
1573-5001
DOI:10.1007/s10858-020-00314-0