Curcumin Improves Biomolecules Associated with Renal Function and Attenuates Oxidative Injury and Histopathological Changes in Potassium-Induced Toxicity in Rats’ Kidney

The protective effect of curcumin on potassium bromate (KBrO 3 )–induced renal damage was investigated in vivo. Treatment with KBrO 3 (20 mg/kg bw) caused a significant increase in arginase and adenosine deaminase (ADA) activities in rats’ kidney. However, oral administration of curcumin (20 mg/kg b...

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Bibliographic Details
Published in:Biological trace element research 2021, Vol.199 (1), p.197-204
Main Authors: Akomolafe, Seun F., Olasehinde, Tosin A., Adewale, Omowumi O., Ajayi, Olubunmi B.
Format: Article
Language:English
Subjects:
Adenosine
Adenosine deaminase
Antioxidants
Arginase
Arginine
Biochemistry
Biocompatibility
Biomarkers
Biomedical and Life Sciences
Biomolecules
Biotechnology
Catalase
Creatinine
Curcumin
Degeneration
Electrolytes
Enzymatic activity
Enzyme activity
Glutathione
Glutathione peroxidase
Histopathology
In vivo methods and tests
Kidneys
Life Sciences
Malondialdehyde
Necrosis
Nitric oxide
Nutrition
Oncology
Oral administration
Original Article
Peroxidase
Potassium
Potassium bromate
Renal function
Serum
Superoxide dismutase
Toxicity
Urea
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Summary:The protective effect of curcumin on potassium bromate (KBrO 3 )–induced renal damage was investigated in vivo. Treatment with KBrO 3 (20 mg/kg bw) caused a significant increase in arginase and adenosine deaminase (ADA) activities in rats’ kidney. However, oral administration of curcumin (20 mg/kg bw) caused a significant reduction in ADA and arginase activities in KBrO 3  + CUR group. Furthermore, nitric oxide level was significantly low in KBrO 3 group compared with the control. After treatment with curcumin in KBrO 3  + CUR group, nitric oxide levels increased significantly ( P  
ISSN:0163-4984
1559-0720
DOI:10.1007/s12011-020-02113-y