Tantalum-Containing Bioactive Glass-Ceramics: A Mechanism of Suppression of the Biological Activity of the 45S5 Bioglass by Doping with Ta2O5

Methods for the synthesis of radiopaque tantalum-containing glass and glass-ceramics by doping 45S5 bioglass with tantalum oxide are presented. Bioactive glass has been obtained by pyrolysis of a mixture of organic precursors: tetraethoxysilane, tributyl phosphate, sodium oleate, and calcium oleate....

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Bibliographic Details
Published in:Russian journal of inorganic chemistry 2020-10, Vol.65 (10), p.1606-1613
Main Authors: Grishchenko, D. N., Slobodyuk, A. B., Kuryavyi, V. G., Medkov, M. A.
Format: Article
Language:English
Subjects:
Bioglass
Biological activity
Biomedical materials
Bones
Calcium
Chemistry
Chemistry and Materials Science
Doping
Glass ceramics
In vitro methods and tests
In vivo methods and tests
Inorganic Chemistry
Inorganic Materials and Nanomaterials
NMR
Nuclear magnetic resonance
Pyrolysis
Regeneration
Tantalum
Tantalum oxides
Tetraethyl orthosilicate
Tissue engineering
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Summary:Methods for the synthesis of radiopaque tantalum-containing glass and glass-ceramics by doping 45S5 bioglass with tantalum oxide are presented. Bioactive glass has been obtained by pyrolysis of a mixture of organic precursors: tetraethoxysilane, tributyl phosphate, sodium oleate, and calcium oleate. Bioglass has been doped with tantalum oxide by three different methods. The mechanism of suppression of the biological activity of materials with an increase in the Ta 2 O 5 content has been studied. The bioactivity of samples containing 1–40 wt % Ta 2 O 5 has been evaluated in vitro using a model medium—an SBF solution. The samples have been studied by 31 P NMR, XRD, SEM, and EDS. A decrease in the concentration of calcium in the glass phase due to the formation of insoluble CaTa 2 O 6 crystals has been considered the major cause of the suppression of the bioactivity of glasses. Samples containing up to 10 wt % Ta 2 O 5 can be used in modern medicine as materials that restore bone tissue. The radiopaque substance in the composition of the biomaterial makes it possible to monitor the process of bone tissue regeneration. Samples containing more than 20 wt % Ta 2 O 5 failed in vitro tests. Due to the dissolution of one of the phases of glass-ceramics in a model solution, the prognosis for the use of such materials in vivo is unfavorable.
ISSN:0036-0236
1531-8613
DOI:10.1134/S0036023620100083