Diagnostic performance of shear wave elastography in discriminating malignant and benign breast lesions

Study aimsWe sought to evaluate the diagnostic performance of quantitative elastography (shear wave elastography) and to establish the optimal cutoff value to differentiate malignant and benign breast lesions using QelaXtoTM software.MethodsWe conducted a retrospective observational study of adult w...

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Bibliographic Details
Published in:Journal of ultrasound 2020-01, Vol.23 (4), p.575-583
Main Authors: Pesce Karina, Binder, Fernando, Chico, María José, Swiecicki María Paz, Galindo, Diana Herbas, Terrasa Sergio
Format: Article
Language:English
Subjects:
Diagnostic systems
Fibrosis
Field of view
Lesions
Neoplasms
Performance evaluation
Sensitivity
Software
Ultrasonic imaging
Ultrasound
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Summary:Study aimsWe sought to evaluate the diagnostic performance of quantitative elastography (shear wave elastography) and to establish the optimal cutoff value to differentiate malignant and benign breast lesions using QelaXtoTM software.MethodsWe conducted a retrospective observational study of adult women with suspicious breast lesions (BIRADS 3, 4 or 5) who underwent programmed ultrasound-guided core biopsies. Breast lesions were assessed using quantitative elastography combined with B-mode ultrasound. Histopathology was used as reference standard. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were estimated, and a ROC curve analysis was conducted. Three elastography cutoff values were considered: 36, 50 and 80 kPa.ResultsWe included 143 women (mean age of 56 years) with a total of 145 breast lesions: 68 benign tumors (47.26%) and 77 malignancies (52.74%). Mean elasticity measurements of benign and malignant lesions were significantly different (24.6 kPa, SD 28.47, vs. 101.49 kPa, SD 47.38, p
ISSN:1971-3495
1876-7931
DOI:10.1007/s40477-020-00481-8