Genes and SNPs in the pathway of immune response and caries risk: a systematic review and meta-analysis

The aim of this systematic review and meta-analysis was to pool the data on Single Nucleotide Polymorphisms (SNPs) in immune response genes associated with dental caries. Nineteen studies were included in the review and 18 in the meta-analysis. Twenty-two SNPs were evaluated, which are linked to six...

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Bibliographic Details
Published in:Biofouling (Chur, Switzerland) Switzerland), 2020-12, Vol.36 (9), p.1100-1116
Main Authors: Chisini, Luiz Alexandre, Cademartori, Mariana Gonzalez, Conde, Marucs Cristian Muniz, Costa, Francine Dos Santos, Tovo-Rodrigues, Luciana, Carvalho, Rodrigo Varella de, Demarco, Flávio Fernando, Correa, Marcos Britto
Format: Article
Language:English
Subjects:
Analysis
beta-Defensins
Cariogenic
Defence mechanisms
Dental caries
Dental Caries - genetics
Dental Caries Susceptibility
DMFT
Genes
genetics
Genotype
Genotypes
Humans
Immune response
Immune system
Immunity
Mannose-Binding Protein-Associated Serine Proteases
MASP-2 protein
Meta-analysis
MUC5B gene
Nucleotides
oral habits
Phenotypes
Polymorphism, Single Nucleotide
Reviews
Single-nucleotide polymorphism
Systematic review
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Summary:The aim of this systematic review and meta-analysis was to pool the data on Single Nucleotide Polymorphisms (SNPs) in immune response genes associated with dental caries. Nineteen studies were included in the review and 18 in the meta-analysis. Twenty-two SNPs were evaluated, which are linked to six different genes (MBL2, LFT, MASP2, DEFB1, FCN2 and MUC5B). Most SNPs (81.8%) are related to the possible functional impact on protein coding. The MBL2 gene was associated with caries experience in the analysis of the homozygote (OR = 2.12 CI95%[1.12-3.99]) and heterozygote (OR = 2.22 CI95%[1.44-3.44]) genotypes. The MUC5B gene was associated according to an analysis of the heterozygous genotype (OR = 1.83 CI95%[1.08-3.09]). Thus, SNPs related to immune response genes are linked to the phenotype of caries experience. Although the meta-analysis showed that the genes MBL2 and MUC5B were associated with caries, these results should be interpreted with caution due to the quality of the evidence.
ISSN:0892-7014
1029-2454
DOI:10.1080/08927014.2020.1856821