Associations of general obesity and central obesity with the risk of hepatocellular carcinoma in a Korean population: A national population‐based cohort study

Numerous previous studies have shown an association between general obesity and hepatocellular carcinoma (HCC). However, relatively few reports on the association of central obesity and HCC are available in Asian populations. Therefore, we investigated the association between WC representing central...

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Bibliographic Details
Published in:International journal of cancer 2021-03, Vol.148 (5), p.1144-1154
Main Authors: Hwang, Seawon, Park, Yong‐Moon, Han, Kyung‐Do, Yun, Jae‐Seung, Ko, Seung‐Hyun, Ahn, Yu‐Bae, Han, Jae Hyun
Format: Article
Language:English
Subjects:
body mass index
Cancer
cohort
Cohort analysis
Hepatocellular carcinoma
Liver cancer
Medical research
Obesity
Population studies
Population-based studies
waist circumference
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Summary:Numerous previous studies have shown an association between general obesity and hepatocellular carcinoma (HCC). However, relatively few reports on the association of central obesity and HCC are available in Asian populations. Therefore, we investigated the association between WC representing central obesity and the risk of HCC in addition to BMI representing general obesity and the risk of HCC in Korea. A total of 10 505 818 participants who received the National Health Insurance Service (NHIS) health checkups in 2009 were screened for study eligibility, and 26 979 cases of HCC occurred during the 7.3 years of mean follow‐up. General obesity increased the risk of HCC with hazard ratios (HRs) of 1.14 (95% CI, 1.11‐1.18) for BMI 25.0‐
ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.33305