Potential of modified Mediterranean diet to improve quality of life and fatigue severity in multiple sclerosis patients: a single-center randomized controlled trial

• Published in: International journal of food properties 2020-01, Vol.23 (1), p.1993-2004
• Main Authors: Moravejolahkami, Amir Reza, Paknahad, Zamzam, Chitsaz, Ahmad, Hojjati Kermani, Mohammad Ali, Borzoo-Isfahani, Mohammad
• Format: Article
• Language: English
• Subjects: Clinical trials; Diet; Fatigue; Mediterranean; Multiple sclerosis; Quality of life; Statistical analysis
• ISSN: 1094-2912; 1532-2386
• DOI: 10.1080/10942912.2020.1840390

Dietary modification may improve quality of life and fatigue severity in Multiple Sclerosis (MS) patients. Given this, there is a growing interest in healthy diets, especially Mediterranean based. The goal of this study was to explore the effects of a modified Mediterranean (mMeD) dietary intervention in Quality Of Life (QOL), and severity of fatigue in MS participants. About 180 Relapsing-Remitting MS patients randomly assigned to follow/not follow the mMeD for 6 months. Primary endpoints were related to dietary adherence and study completion. Clinical endpoints were evaluated Multiple Sclerosis Quality Of Life-54 items, Fatigue Severity Scale (FSS-9), and Visual Analog Fatigue Scale. Data were analyzed by SPSS 24 . Of 261 screened patients (July 2018-February 2019), 180 were eligible and willing to commit. 68/90 as mMeD and 79/90 as control group completed the study. Self-reported adherence was excellent (95%). The majority of mean changes for QOL were statistically significant (P