A new straightforward approach to 3-(arylideneamino)hydantoins

A novel straightforward approach to 3-(arylideneamino)hydantoins has been developed. It is based on the reaction of readily available 4-(tosylmethyl)semicarbazones with NaCN in DMF followed by heating of the obtained 4-(cyanomethyl)semicarbazones with concd HCl.

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Bibliographic Details
Published in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2020-12, Vol.56 (12), p.1535-1541
Main Authors: Yankov, Alexander N., Shutalev, Anatoly D.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Organic Chemistry
Pharmacy
Sodium cyanide
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Summary:A novel straightforward approach to 3-(arylideneamino)hydantoins has been developed. It is based on the reaction of readily available 4-(tosylmethyl)semicarbazones with NaCN in DMF followed by heating of the obtained 4-(cyanomethyl)semicarbazones with concd HCl.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-020-02846-7