Circulating miR‐15b, miR‐34a and miR‐218 as promising novel early low‐invasive biomarkers of cervical carcinogenesis

Circulating biological markers, such as miRNAs, hold the greatest possibilities to complement tissue biopsy and clinical diagnostic tests. The objective of this study was to evaluate the relative abundance of three circulating miRNAs in serum from 17 HPV16‐positive patients with early cervical lesio...

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Published in:APMIS : acta pathologica, microbiologica et immunologica Scandinavica microbiologica et immunologica Scandinavica, 2021-02, Vol.129 (2), p.70-79
Main Authors: Ocadiz‐Delgado, Rodolfo, Lizcano‐Meneses, Solangy, Trejo‐Vazquez, Jessica‐Angelina, Conde‐Perezprina, Juan‐Cristobal, Garrido‐Palmas, Frida, Alvarez‐Rios, Elizabeth, García‐Villa, Enrique, Ruiz, Graciela, Illades‐Aguiar, Berenice, Leyva‐Vázquez, Marco Antonio, García‐Carrancá, Alejandro, Gariglio, Patricio
Format: Article
Language:English
Subjects:
Adult
Biomarkers
Biomarkers, Tumor - blood
Biomarkers, Tumor - genetics
Biopsy
Carcinogenesis
Carcinogenesis - genetics
Carcinogens
Carcinoma, Squamous Cell - blood
Carcinoma, Squamous Cell - genetics
Cervical Intraepithelial Neoplasia - blood
Cervical Intraepithelial Neoplasia - genetics
Cervix
Cervix Uteri - pathology
Circulating MicroRNA - blood
Cyclin D1
Diagnostic systems
early biomarkers
Epithelium
Female
Gene expression
Gene Expression Regulation, Neoplastic - genetics
Genotype
Homology
HPV
Human papillomavirus 16 - genetics
Human papillomavirus 16 - isolation & purification
Humans
Invasiveness
Lesions
LSIL
Lymphoma
microRNA expression
MicroRNAs
MicroRNAs - blood
MicroRNAs - genetics
Middle Aged
miRNA
Papillomavirus Infections - genetics
Relative abundance
Squamous cell carcinoma
Statistical analysis
Statistical methods
Uterine Cervical Neoplasms - blood
Uterine Cervical Neoplasms - genetics
Young Adult
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Summary:Circulating biological markers, such as miRNAs, hold the greatest possibilities to complement tissue biopsy and clinical diagnostic tests. The objective of this study was to evaluate the relative abundance of three circulating miRNAs in serum from 17 HPV16‐positive patients with early cervical lesions known as Low‐Grade Squamous Intraepithelial Lesions (LSILs). The expression of circulating microRNAs miR‐15b, miR‐34a and miR‐218 in patients with LSILs was compared to 23 HPV‐negative individuals showing normal cervical epithelium (healthy women) and 23 Squamous Cell Carcinoma (SCC) samples. The expression levels of miR‐15b remained unchanged while those of miRNAs 34a and 218 were relatively high in serum obtained from LSIL patients in comparison with healthy women (results were statistically significant with a p of 
ISSN:0903-4641
1600-0463
DOI:10.1111/apm.13093