The versatility of carbohydrates in antimicrobial applications

The worsening situation of global drug resistance is urgently demanding for novel antimicrobial agents. Considerable efforts have been concentrated on developing new antibacterial therapies with new mode of actions, exerting no selective pressure on bacterial mutation, and minimizing toxicity to hos...

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Bibliographic Details
Published in:Journal of the Chinese Chemical Society (Taipei) 2020-12, Vol.67 (12), p.2204-2207
Main Authors: Xu, Yuan, Liu, Xue‐Wei
Format: Article
Language:English
Subjects:
Antiinfectives and antibacterials
antimicrobial
Antimicrobial agents
Biological activity
Carbohydrates
Drug resistance
Mutation
Selectivity
targeting
Toxicity
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Summary:The worsening situation of global drug resistance is urgently demanding for novel antimicrobial agents. Considerable efforts have been concentrated on developing new antibacterial therapies with new mode of actions, exerting no selective pressure on bacterial mutation, and minimizing toxicity to host cells. In this context, active targeting can greatly contribute to selectivity between pathogens and mammalian cells in which carbohydrates, playing important roles in numerous biological processes, can be employed as targeting ligands or “trojan horse.” This short account has discussed the recent results of carbohydrate‐based antimicrobial agents developed by our group. Other excellent works by other scientists and possible directions in the future are also discussed. A short account of the recent development of carbohydrate‐based antimicrobial agents has been presented. The different roles played by carbohydrates as well as possible directions in the future have been discussed.
ISSN:0009-4536
2192-6549
DOI:10.1002/jccs.202000356