Novel therapies for treatment of resistant and refractory nontuberculous mycobacterial infections in patients with cystic fibrosis

Respiratory infections caused by non‐tuberculous mycobacteria (NTM) are a major cause of morbidity for patients living with cystic fibrosis (CF), as NTM pulmonary disease (NTM‐PD) is challenging to both diagnose and eradicate. Despite the lengthy courses of the established regimens recommended by th...

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Bibliographic Details
Published in:Pediatric pulmonology 2021-02, Vol.56 (S1), p.S55-S68
Main Authors: Laudone, Thomas W., Garner, Lauren, Kam, Charissa W., Esther, Charles R., McKinzie, Cameron J.
Format: Article
Language:English
Subjects:
Antibiotics
Bacterial infections
Cystic fibrosis
nontuberculous mycobacteria
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Summary:Respiratory infections caused by non‐tuberculous mycobacteria (NTM) are a major cause of morbidity for patients living with cystic fibrosis (CF), as NTM pulmonary disease (NTM‐PD) is challenging to both diagnose and eradicate. Despite the lengthy courses of the established regimens recommended by the Cystic Fibrosis Foundation (CFF) and European Cystic Fibrosis Society (ECFS) consensus guidelines, only about 50% to 60% of patients achieve culture conversion, and treatment regimens are often complicated by antibiotic resistance and toxicities. Since publication of the CFF/ECFS guidelines, several new or alternative antibiotic regimens have been described for patients with CF who have NTM‐PD. These regimens offer new options for patients who do not clear NTM with standard therapies or cannot utilize the usual regimens due to toxicities or drug‐drug interactions.
ISSN:8755-6863
1099-0496
DOI:10.1002/ppul.24939