Fibulin-3 immunoexpression in malignant mesothelioma due to fluoro-edenite: a preliminary report

An increased standardized incidence and mortality rate were reported due to malignant mesothelioma (MM) in Biancavilla. Environmental investigations showed the presence of an asbestiform fiber: fluoro-edenite (FE). MM develops with a latency of 20-60 years from exposure and specific and sensitive bi...

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Bibliographic Details
Published in:Future oncology (London, England) England), 2018-03, Vol.14 (6s), p.53-57
Main Authors: Caltabiano, Rosario, Loreto, Carla, Vitale, Ermanno, Matera, Serena, Miozzi, Edoardo, Migliore, Marcello, Angelico, Giuseppe, Tumino, Rosario, Ledda, Caterina, Rapisarda, Venerando
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Antibodies
Asbestos
Asbestos, Amphibole - toxicity
Biomarkers
Biomarkers, Tumor - metabolism
Biopsy
Cancer
Carcinogens
EFEMP-1
Environmental Exposure - adverse effects
Extracellular Matrix Proteins - metabolism
Female
Follow-Up Studies
Humans
Incidence
Lung - pathology
Lung Neoplasms - chemically induced
Lung Neoplasms - epidemiology
Lung Neoplasms - pathology
Male
Medical prognosis
Mesothelioma
Mesothelioma - chemically induced
Mesothelioma - epidemiology
Mesothelioma - pathology
Mesothelioma, Malignant
Middle Aged
molecular oncology
Mortality
oncogenes
Plasma
Prognosis
Proteins
Retrospective Studies
Sicily - epidemiology
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Summary:An increased standardized incidence and mortality rate were reported due to malignant mesothelioma (MM) in Biancavilla. Environmental investigations showed the presence of an asbestiform fiber: fluoro-edenite (FE). MM develops with a latency of 20-60 years from exposure and specific and sensitive biomarkers are urgently needed. For this purpose, we evaluated Fibulin-3 (Fb-3) immunoexpression in human cases of MM related to FE exposure and its prognostic role. Immunohistochemical analysis of Fb-3 was carried out in eight MM patients resident in Biancavilla and the analysis showed evidence of environmental exposure to FE fibers. Six MM cases (3 epithelioid and 3 biphasic) showed a high immunoexpression of Fb-3 in neoplastic cells with nuclear and cytoplasmic localization. One epithelioid and one biphasic subtype did not show Fb-3 immunostaining. The results demonstrate the implication of Fb-3 in MM due to FE exposure and may possibly suggest its potential role as a diagnostic and prognostic marker.
ISSN:1479-6694
1744-8301
DOI:10.2217/fon-2017-0386