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Fibulin-3 immunoexpression in malignant mesothelioma due to fluoro-edenite: a preliminary report
An increased standardized incidence and mortality rate were reported due to malignant mesothelioma (MM) in Biancavilla. Environmental investigations showed the presence of an asbestiform fiber: fluoro-edenite (FE). MM develops with a latency of 20-60 years from exposure and specific and sensitive bi...
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| Published in: | Future oncology (London, England) England), 2018-03, Vol.14 (6s), p.53-57 |
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| container_end_page | 57 |
| container_issue | 6s |
| container_start_page | 53 |
| container_title | Future oncology (London, England) |
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| creator | Caltabiano, Rosario Loreto, Carla Vitale, Ermanno Matera, Serena Miozzi, Edoardo Migliore, Marcello Angelico, Giuseppe Tumino, Rosario Ledda, Caterina Rapisarda, Venerando |
| description | An increased standardized incidence and mortality rate were reported due to malignant mesothelioma (MM) in Biancavilla. Environmental investigations showed the presence of an asbestiform fiber: fluoro-edenite (FE). MM develops with a latency of 20-60 years from exposure and specific and sensitive biomarkers are urgently needed. For this purpose, we evaluated Fibulin-3 (Fb-3) immunoexpression in human cases of MM related to FE exposure and its prognostic role. Immunohistochemical analysis of Fb-3 was carried out in eight MM patients resident in Biancavilla and the analysis showed evidence of environmental exposure to FE fibers. Six MM cases (3 epithelioid and 3 biphasic) showed a high immunoexpression of Fb-3 in neoplastic cells with nuclear and cytoplasmic localization. One epithelioid and one biphasic subtype did not show Fb-3 immunostaining. The results demonstrate the implication of Fb-3 in MM due to FE exposure and may possibly suggest its potential role as a diagnostic and prognostic marker. |
| doi_str_mv | 10.2217/fon-2017-0386 |
| format | article |
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Environmental investigations showed the presence of an asbestiform fiber: fluoro-edenite (FE). MM develops with a latency of 20-60 years from exposure and specific and sensitive biomarkers are urgently needed. For this purpose, we evaluated Fibulin-3 (Fb-3) immunoexpression in human cases of MM related to FE exposure and its prognostic role. Immunohistochemical analysis of Fb-3 was carried out in eight MM patients resident in Biancavilla and the analysis showed evidence of environmental exposure to FE fibers. Six MM cases (3 epithelioid and 3 biphasic) showed a high immunoexpression of Fb-3 in neoplastic cells with nuclear and cytoplasmic localization. One epithelioid and one biphasic subtype did not show Fb-3 immunostaining. The results demonstrate the implication of Fb-3 in MM due to FE exposure and may possibly suggest its potential role as a diagnostic and prognostic marker.</description><identifier>ISSN: 1479-6694</identifier><identifier>EISSN: 1744-8301</identifier><identifier>DOI: 10.2217/fon-2017-0386</identifier><identifier>PMID: 29664355</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>Aged ; Aged, 80 and over ; Antibodies ; Asbestos ; Asbestos, Amphibole - toxicity ; Biomarkers ; Biomarkers, Tumor - metabolism ; Biopsy ; Cancer ; Carcinogens ; EFEMP-1 ; Environmental Exposure - adverse effects ; Extracellular Matrix Proteins - metabolism ; Female ; Follow-Up Studies ; Humans ; Incidence ; Lung - pathology ; Lung Neoplasms - chemically induced ; Lung Neoplasms - epidemiology ; Lung Neoplasms - pathology ; Male ; Medical prognosis ; Mesothelioma ; Mesothelioma - chemically induced ; Mesothelioma - epidemiology ; Mesothelioma - pathology ; Mesothelioma, Malignant ; Middle Aged ; molecular oncology ; Mortality ; oncogenes ; Plasma ; Prognosis ; Proteins ; Retrospective Studies ; Sicily - epidemiology</subject><ispartof>Future oncology (London, England), 2018-03, Vol.14 (6s), p.53-57</ispartof><rights>2018 Future Medicine Ltd</rights><rights>Copyright Future Medicine Ltd Mar 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-e412e6475693204399ef3ed274dd1f72994f31299e33549912b3020715684d113</citedby><cites>FETCH-LOGICAL-c399t-e412e6475693204399ef3ed274dd1f72994f31299e33549912b3020715684d113</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29664355$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Caltabiano, Rosario</creatorcontrib><creatorcontrib>Loreto, Carla</creatorcontrib><creatorcontrib>Vitale, Ermanno</creatorcontrib><creatorcontrib>Matera, Serena</creatorcontrib><creatorcontrib>Miozzi, Edoardo</creatorcontrib><creatorcontrib>Migliore, Marcello</creatorcontrib><creatorcontrib>Angelico, Giuseppe</creatorcontrib><creatorcontrib>Tumino, Rosario</creatorcontrib><creatorcontrib>Ledda, Caterina</creatorcontrib><creatorcontrib>Rapisarda, Venerando</creatorcontrib><title>Fibulin-3 immunoexpression in malignant mesothelioma due to fluoro-edenite: a preliminary report</title><title>Future oncology (London, England)</title><addtitle>Future Oncol</addtitle><description>An increased standardized incidence and mortality rate were reported due to malignant mesothelioma (MM) in Biancavilla. Environmental investigations showed the presence of an asbestiform fiber: fluoro-edenite (FE). MM develops with a latency of 20-60 years from exposure and specific and sensitive biomarkers are urgently needed. For this purpose, we evaluated Fibulin-3 (Fb-3) immunoexpression in human cases of MM related to FE exposure and its prognostic role. Immunohistochemical analysis of Fb-3 was carried out in eight MM patients resident in Biancavilla and the analysis showed evidence of environmental exposure to FE fibers. Six MM cases (3 epithelioid and 3 biphasic) showed a high immunoexpression of Fb-3 in neoplastic cells with nuclear and cytoplasmic localization. One epithelioid and one biphasic subtype did not show Fb-3 immunostaining. The results demonstrate the implication of Fb-3 in MM due to FE exposure and may possibly suggest its potential role as a diagnostic and prognostic marker.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antibodies</subject><subject>Asbestos</subject><subject>Asbestos, Amphibole - toxicity</subject><subject>Biomarkers</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Biopsy</subject><subject>Cancer</subject><subject>Carcinogens</subject><subject>EFEMP-1</subject><subject>Environmental Exposure - adverse effects</subject><subject>Extracellular Matrix Proteins - metabolism</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Incidence</subject><subject>Lung - pathology</subject><subject>Lung Neoplasms - chemically induced</subject><subject>Lung Neoplasms - epidemiology</subject><subject>Lung Neoplasms - pathology</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Mesothelioma</subject><subject>Mesothelioma - chemically induced</subject><subject>Mesothelioma - epidemiology</subject><subject>Mesothelioma - pathology</subject><subject>Mesothelioma, Malignant</subject><subject>Middle Aged</subject><subject>molecular oncology</subject><subject>Mortality</subject><subject>oncogenes</subject><subject>Plasma</subject><subject>Prognosis</subject><subject>Proteins</subject><subject>Retrospective Studies</subject><subject>Sicily - epidemiology</subject><issn>1479-6694</issn><issn>1744-8301</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kD1PwzAQhi0EoqUwsiJLzAZ_JY7ZUEUBqRILzCZNLuAqsYsdS_DvcdXCBtPdWc-9Jz8InTN6xTlT1513hFOmCBVVeYCmTElJKkHZYe6l0qQstZygkxjXlEolCnqMJlyXpRRFMUWvC7tKvXVEYDsMyXn43ASI0XqHrcND3ds3V7sRDxD9-A699UON2wR49Ljrkw-eQAvOjnCDa5x3eztYV4cvHGDjw3iKjrq6j3C2rzP0srh7nj-Q5dP94_x2SRqh9UhAMg6lVEWpBacyv0EnoOVKti3rFNdadoLlAkIUUmvGV4JyqlhRVrJlTMzQ5S53E_xHgjiatU_B5ZOGS6W4qpgQ_1JcFZqJgleZIjuqCT7GAJ3ZBDvkPxlGzda6ydbN1rrZWs_8xT41rQZof-kfzRnQO6BLY8p6GwuuAbOb8oZtrIM_wr8BeA2PVg</recordid><startdate>20180301</startdate><enddate>20180301</enddate><creator>Caltabiano, Rosario</creator><creator>Loreto, Carla</creator><creator>Vitale, Ermanno</creator><creator>Matera, Serena</creator><creator>Miozzi, Edoardo</creator><creator>Migliore, Marcello</creator><creator>Angelico, Giuseppe</creator><creator>Tumino, Rosario</creator><creator>Ledda, Caterina</creator><creator>Rapisarda, Venerando</creator><general>Future Medicine Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20180301</creationdate><title>Fibulin-3 immunoexpression in malignant mesothelioma due to fluoro-edenite: a preliminary report</title><author>Caltabiano, Rosario ; Loreto, Carla ; Vitale, Ermanno ; Matera, Serena ; Miozzi, Edoardo ; Migliore, Marcello ; Angelico, Giuseppe ; Tumino, Rosario ; Ledda, Caterina ; Rapisarda, Venerando</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-e412e6475693204399ef3ed274dd1f72994f31299e33549912b3020715684d113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antibodies</topic><topic>Asbestos</topic><topic>Asbestos, Amphibole - toxicity</topic><topic>Biomarkers</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Biopsy</topic><topic>Cancer</topic><topic>Carcinogens</topic><topic>EFEMP-1</topic><topic>Environmental Exposure - adverse effects</topic><topic>Extracellular Matrix Proteins - metabolism</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Incidence</topic><topic>Lung - pathology</topic><topic>Lung Neoplasms - chemically induced</topic><topic>Lung Neoplasms - epidemiology</topic><topic>Lung Neoplasms - pathology</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Mesothelioma</topic><topic>Mesothelioma - chemically induced</topic><topic>Mesothelioma - epidemiology</topic><topic>Mesothelioma - pathology</topic><topic>Mesothelioma, Malignant</topic><topic>Middle Aged</topic><topic>molecular oncology</topic><topic>Mortality</topic><topic>oncogenes</topic><topic>Plasma</topic><topic>Prognosis</topic><topic>Proteins</topic><topic>Retrospective Studies</topic><topic>Sicily - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Caltabiano, Rosario</creatorcontrib><creatorcontrib>Loreto, Carla</creatorcontrib><creatorcontrib>Vitale, Ermanno</creatorcontrib><creatorcontrib>Matera, Serena</creatorcontrib><creatorcontrib>Miozzi, Edoardo</creatorcontrib><creatorcontrib>Migliore, Marcello</creatorcontrib><creatorcontrib>Angelico, Giuseppe</creatorcontrib><creatorcontrib>Tumino, Rosario</creatorcontrib><creatorcontrib>Ledda, Caterina</creatorcontrib><creatorcontrib>Rapisarda, Venerando</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection (ProQuest Medical & Health Databases)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>UK & Ireland Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Future oncology (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Caltabiano, Rosario</au><au>Loreto, Carla</au><au>Vitale, Ermanno</au><au>Matera, Serena</au><au>Miozzi, Edoardo</au><au>Migliore, Marcello</au><au>Angelico, Giuseppe</au><au>Tumino, Rosario</au><au>Ledda, Caterina</au><au>Rapisarda, Venerando</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fibulin-3 immunoexpression in malignant mesothelioma due to fluoro-edenite: a preliminary report</atitle><jtitle>Future oncology (London, England)</jtitle><addtitle>Future Oncol</addtitle><date>2018-03-01</date><risdate>2018</risdate><volume>14</volume><issue>6s</issue><spage>53</spage><epage>57</epage><pages>53-57</pages><issn>1479-6694</issn><eissn>1744-8301</eissn><abstract>An increased standardized incidence and mortality rate were reported due to malignant mesothelioma (MM) in Biancavilla. Environmental investigations showed the presence of an asbestiform fiber: fluoro-edenite (FE). MM develops with a latency of 20-60 years from exposure and specific and sensitive biomarkers are urgently needed. For this purpose, we evaluated Fibulin-3 (Fb-3) immunoexpression in human cases of MM related to FE exposure and its prognostic role. Immunohistochemical analysis of Fb-3 was carried out in eight MM patients resident in Biancavilla and the analysis showed evidence of environmental exposure to FE fibers. Six MM cases (3 epithelioid and 3 biphasic) showed a high immunoexpression of Fb-3 in neoplastic cells with nuclear and cytoplasmic localization. One epithelioid and one biphasic subtype did not show Fb-3 immunostaining. The results demonstrate the implication of Fb-3 in MM due to FE exposure and may possibly suggest its potential role as a diagnostic and prognostic marker.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>29664355</pmid><doi>10.2217/fon-2017-0386</doi><tpages>5</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Antibodies Asbestos Asbestos, Amphibole - toxicity Biomarkers Biomarkers, Tumor - metabolism Biopsy Cancer Carcinogens EFEMP-1 Environmental Exposure - adverse effects Extracellular Matrix Proteins - metabolism Female Follow-Up Studies Humans Incidence Lung - pathology Lung Neoplasms - chemically induced Lung Neoplasms - epidemiology Lung Neoplasms - pathology Male Medical prognosis Mesothelioma Mesothelioma - chemically induced Mesothelioma - epidemiology Mesothelioma - pathology Mesothelioma, Malignant Middle Aged molecular oncology Mortality oncogenes Plasma Prognosis Proteins Retrospective Studies Sicily - epidemiology |
| title | Fibulin-3 immunoexpression in malignant mesothelioma due to fluoro-edenite: a preliminary report |
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