Second primary neoplasms in patients with primary orbital lymphoma: a population‐based study 1992 to 2016

Purpose To investigate, in a population‐based study, the risk of developing second primary neoplasms (SPNs) after a diagnosis of primary orbital lymphoma (OL). Methods Data on a cohort of patients with a diagnosis of primary OL as their first malignancy were extracted from the Surveillance, Epidemio...

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Bibliographic Details
Published in:Acta ophthalmologica (Oxford, England) England), 2021-01, Vol.99 (S265), p.n/a
Main Authors: Tadrosse, Abanoob, Mikhael, Sandra, Tadrosse, Marina, Tadrosse, Mark, Langer, Paul D.
Format: Article
Language:English
Subjects:
Cancer
Colorectal cancer
Colorectal carcinoma
Diagnosis
Epidemiology
Lymphoma
Malignancy
Population studies
Prostate
Prostate cancer
Radiation therapy
Respiratory tract
Surveillance
Thyroid
Thyroid cancer
Thyroid gland
Tumors
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Summary:Purpose To investigate, in a population‐based study, the risk of developing second primary neoplasms (SPNs) after a diagnosis of primary orbital lymphoma (OL). Methods Data on a cohort of patients with a diagnosis of primary OL as their first malignancy were extracted from the Surveillance, Epidemiology, and End Results US registry from 1992 to 2016. Observed‐to‐expected ratio of developing SPNs was calculated to estimate relative risk (RR) and associated 95% confidence interval (CI), which were compared to a reference population (RP) matched for age, sex, race, and calendar year. Results A total of 1063 patients with primary OL were identified, 14% of whom developed SPNs. Mean age at OL diagnosis was 66 years old, while that at a SPN diagnosis was 74. There was a significant 20% excess risk of SPNs development in OL patients compared to the RP (p 
ISSN:1755-375X
1755-3768
DOI:10.1111/j.1755-3768.20200233