Amphiphilic copolymers with light-pH-temperature triple stimuli-responses: Preparation, self-assembly and controlled drug release

[Display omitted] •The amphiphilic copolymer containing spiropyran groups was synthesized.•The copolymer present light-temperature-pH triple-stimuli responsive properties.•The morphologies of the copolymer micelles could be adjusted.•The controlled release of DOX could be achieved from copolymer mic...

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Bibliographic Details
Published in:Materials letters 2021-02, Vol.284, p.129008, Article 129008
Main Authors: Jiang, Miao, Gao, Xueyuan, Zhao, Nuoya, Cheng, Xiaoyun, Yuan, Weizhong
Format: Article
Language:English
Subjects:
Anthocyanins
Biomaterials
Controlled release
Copolymers
Doxorubicin
Ethylene glycol
Functional
Materials science
Micelles
Morphology
Polymers
Polymethacrylic acid
Segments
Self-assembly
Spiropyran
Spiropyrans
Stimuli
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Summary:[Display omitted] •The amphiphilic copolymer containing spiropyran groups was synthesized.•The copolymer present light-temperature-pH triple-stimuli responsive properties.•The morphologies of the copolymer micelles could be adjusted.•The controlled release of DOX could be achieved from copolymer micelles. Poly(2-(2-methoxyethoxy)ethylmethacrylate-co-oligo(ethylene glycol) methacrylate)-block-poly(methacrylic acid-co-spiropyran methacrylate) (P(MEO2MA-co-OEGMA)-b-P(MAA-co-SPMA)) was prepared by atom transfer radical polymerization (ATRP), acidolysis and dicyclohexylcarbodiimide (DCC) reaction and can self-assemble into spherical micelles. Poly(2-(2-methoxyethoxy)ethylmethacrylate-co-oligo(ethylene glycol) methacrylate) (P(MEO2MA-co-OEGMA)) segment can respond to changes in temperature, and poly(methacrylic acid) (PMAA) segments show pH-responsive property. The reversible conversion between spiropyran (SP) which is hydrophobic and hydrophilic anthocyanins H+(MCH)/anthocyanins (MC) makes the poly(spiropyran methacrylate) (PSPMA) segments show light-pH-temperature triple-stimulus responses. As a result, the micelles presented light, pH and temperature triple stimuli-responsive properties. The micelles showed different sizes and morphologies under different environmental stimuli. Therefore, the intelligent micelles could be used as the carrier for the multiple controlled release of doxorubicin (DOX) drug molecules.
ISSN:0167-577X
1873-4979
DOI:10.1016/j.matlet.2020.129008