FRET-based fluorescent probe for drug assay from amino acid@gold-carbon nanoparticles

Biocompatible and luminescent nanostructures synthesized by capping gold-carbon nanoparticles (HOOC-4-C 6 H 4 -AuNPs) with amino acids tyrosine, tryptophan, and cysteine were used for the quantitative estimation of ranitidine (RNH), a peptic ulcer and gastroesophageal reflux drug. We applied a fluor...

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Published in:Analytical and bioanalytical chemistry 2021-02, Vol.413 (4), p.1117-1125
Main Authors: Hameed, Mehavesh K., Parambath, Javad B. M., Kanan, Sofian M., Mohamed, Ahmed A.
Format: Article
Language:English
Subjects:
Amino acids
Analytical Chemistry
Biochemistry
Biocompatibility
Carbon
Characterization and Evaluation of Materials
Chemical properties
Chemistry
Chemistry and Materials Science
Composition
Energy transfer
Fluorescence
Fluorescence resonance energy transfer
Fluorescent indicators
Food Science
Gastroesophageal reflux
Gold
Laboratory Medicine
Monitoring/Environmental Analysis
Nanoparticles
Peptic ulcers
Quenching
Ranitidine
Research Paper
Tryptophan
Tyrosine
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description Biocompatible and luminescent nanostructures synthesized by capping gold-carbon nanoparticles (HOOC-4-C 6 H 4 -AuNPs) with amino acids tyrosine, tryptophan, and cysteine were used for the quantitative estimation of ranitidine (RNH), a peptic ulcer and gastroesophageal reflux drug. We applied a fluorescence quenching mechanism to investigate the viability of the energy transfer based on gold-carbon nanosensors. Förster resonance energy transfer (FRET) calculations showed a donor–acceptor distance of 1.69 nm (Tyr@AuNPs), 2.27 nm (Trp@AuNPs), and 2.32 nm (Cys@AuNPs). The constant time-resolved fluorescence lifetime measurements supported the static quenching nature. This method was successfully utilized in the detection and quantification of RNH, with a limit of detection (LOD) of 0.174, 0.56, and 0.332 μM for Tyr@AuNP, Trp@AuNP, and Cys@AuNP bioconjugates, respectively. This approach was also successful in the quantification of RNH in spiked serum samples.
doi_str_mv 10.1007/s00216-020-03075-9
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subjects Amino acids
Analytical Chemistry
Biochemistry
Biocompatibility
Carbon
Characterization and Evaluation of Materials
Chemical properties
Chemistry
Chemistry and Materials Science
Composition
Energy transfer
Fluorescence
Fluorescence resonance energy transfer
Fluorescent indicators
Food Science
Gastroesophageal reflux
Gold
Laboratory Medicine
Monitoring/Environmental Analysis
Nanoparticles
Peptic ulcers
Quenching
Ranitidine
Research Paper
Tryptophan
Tyrosine
title FRET-based fluorescent probe for drug assay from amino acid@gold-carbon nanoparticles
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