A novel H2S releasing-monastrol hybrid (MADTOH) inhibits L-type calcium channels

A new alleged monastrol-H2S releasing hybrid, named MADTOH, was designed based on the structure of monastrol (M) and 5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione (ADTOH) and synthesized in 7.8% overall yield. MADTOH was shown to be an H2S donor under physiological conditions. In addition, the hybrid...

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Bibliographic Details
Published in:New journal of chemistry 2021-01, Vol.45 (2), p.671-678
Main Authors: Taniris Cafiero Braga, Itamar Couto Guedes de Jesus, Kathleen Viveiros Soares, Guatimosim, Silvia, Leonardo da Silva Neto, da-Silva, Cristiane Jovelina, Modolo, Luzia Valentina, José Evaldo Rodrigues Menezes Filho, Rhana, Paula, Jader Santos Cruz, Ângelo de Fátima
Format: Article
Language:English
Subjects:
Calcium ions
Cardiomyocytes
Hydrogen sulfide
Online Access:Get full text
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Summary:A new alleged monastrol-H2S releasing hybrid, named MADTOH, was designed based on the structure of monastrol (M) and 5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione (ADTOH) and synthesized in 7.8% overall yield. MADTOH was shown to be an H2S donor under physiological conditions. In addition, the hybrid causes a decrease in global calcium transient in cardiomyocytes similar to nifedipine (NIFE), taken as a positive control. Whole-cell voltage-clamp showed that MADTOH decreases L-type Ca2+ current in isolated ventricular cardiomyocytes.
ISSN:1144-0546
1369-9261
DOI:10.1039/d0nj04415f