Antibacterial activity and in vitro cytotoxicity studies of Ag-doped CaO nanoparticles

• Published in: Materials letters 2021-01, Vol.283, p.128741, Article 128741
• Main Authors: López-Badillo, C.M., Hernández-González, M., Hernández-Centeno, F., Olivas-Armendáriz, I., Rodríguez-González, C.A., Múzquiz-Ramos, E.M., López-Cuevas, J., López-De la Peña, H.Y.
• Format: Article
• Language: English
• Subjects: Ag-doped; Antimicrobial activity; Antimicrobial agents; CaO; Cytotoxicity; Food; Materials science; Nanoparticles; Silver; Sol-gel processes; Toxicity
• ISSN: 0167-577X; 1873-4979
• DOI: 10.1016/j.matlet.2020.128741

[Display omitted] •Ag-doped CaO nanoparticles were synthesized by sol-gel method.•The obtained nanoparticles have shown good antimicrobial activity.•Ag-doped CaO nanoparticles exhibited cell growth promotion as well as non-cytotoxic effect. CaO nanoparticles can be used in different fields, such as medical and food, some studies suggest that they have poor antimicrobial properties. In this work, CaO nanoparticles doped with different concentrations of Ag were synthesized by the sol-gel method, to improve their antimicrobial activity. Cytotoxicity was also determined by MTT assay. The results of this study showed that it was possible to increase the antimicrobial activity of the CaO nanoparticles by doping them with different concentrations of Ag. According to a cytotoxicity study, a percentage of cell viability above 70% was obtained, thus the nanoparticles of CaO doped with Ag are candidates to be used in medical and food applications.