Nanoparticles with PDT and PTT synergistic properties working with dual NIR-light source simultaneously

A non-toxic nano system using a cleverly designed dual light can be an important treatment strategy in cancer therapy. Here, we propose a unique concept of synergistic non-toxic nanoplatform, which operates with dual light. An apoferritin nano-platform whose surface was modified with Verteporfin (Vi...

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Bibliographic Details
Published in:RSC advances 2021-01, Vol.11 (4), p.2383-2389
Main Authors: Sozmen, Fazli, Kucukoflaz, Merve, Ergul, Mustafa, Sahin Inan, Zeynep Deniz
Format: Article
Language:English
Subjects:
Copper sulfides
Light emitting diodes
Light sources
Nanoparticles
Photodynamic therapy
Synergistic effect
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Summary:A non-toxic nano system using a cleverly designed dual light can be an important treatment strategy in cancer therapy. Here, we propose a unique concept of synergistic non-toxic nanoplatform, which operates with dual light. An apoferritin nano-platform whose surface was modified with Verteporfin (Visudyne®) and with ultra-small CuS nanoparticles in the center demonstrated the synergistic effect of photodynamic therapy (PDT) and photothermal therapy (PTT). The synergistic effect of PDT and PTT were achieved with 808 nm laser light and 690 nm LED light, respectively. These results not only give a new horizon to multifunctional nanostructures for biological applications but also show a new way to design the novel PDT and PTT agents. A non-toxic nano system using a cleverly designed dual light can be an important treatment strategy in cancer therapy.
ISSN:2046-2069
2046-2069
DOI:10.1039/d0ra09954f