Structure Based Virtual Screening, Design, Synthesis and Biological Evaluation of Imidazoles as Anti-Diabetic Agents

Virtual screening is a promising method for obtaining novel hit compounds in drug discovery. In the present study, SBVS is performed for imidazole using CHEMBLE database for different activities as antifungal, anticancer, antidiabetic, antibacterial.Among all screened derivatives, imidazoloneswere r...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences and research 2020-12, Vol.12 (12), p.1515-1526
Main Authors: Sreelatha, K, Sanobar, Syeda Advia, Sruthi, K, Sumakanth, M
Format: Article
Language:English
Subjects:
Adipocytes
Antidiabetics
Diabetes
Glucose
Insulin resistance
Ligands
Metabolism
Musculoskeletal system
NMR
Nuclear magnetic resonance
Potassium
Proteins
Signal transduction
Software
Spectrum analysis
Transcription factors
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Summary:Virtual screening is a promising method for obtaining novel hit compounds in drug discovery. In the present study, SBVS is performed for imidazole using CHEMBLE database for different activities as antifungal, anticancer, antidiabetic, antibacterial.Among all screened derivatives, imidazoloneswere reported to have antidiabetic activity against SUR-1 receptors And also theseimidazoloneswere simultaneouslysubjected to virtualscreening PPARy receptors (as they are structurally similar to imidazolones) and were designed to emerge them as synergistic inhibitors of SUR-1 & PPARy for their possible antidiabetic activity.Then the HITS were identified and basic pharmacophoric features responsible for the activity were predicted. By keeping in view of these novel imidazolone derivatives were designed, docked and synthesized. The Synthesized compounds were characterized by physical and spectral data.
ISSN:0975-1459