SERPINB2—its regulation and interplay with aryl hydrocarbon receptor

Despite many years of intensive investigation, real biological role of SERPINB2 is largely unknown. However, recent high throughput studies suggest its function in inflammation, influence on autoimmune disorders, and modulation of processes leading to carcinogenesis. SERPINB2 expression is acutely u...

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Bibliographic Details
Published in:Journal of applied genetics 2021-02, Vol.62 (1), p.99-105
Main Author: Brauze, Damian
Format: Article
Language:English
Subjects:
Animal Genetics and Genomics
Aromatic compounds
Autoimmune diseases
Biomedical and Life Sciences
Carcinogenesis
Carcinogens
Chymotrypsin
Gene expression
Genes
Human Genetics
Human Genetics • Review
Hydrocarbons
Inflammation
Life Sciences
Microbial Genetics and Genomics
Plant Genetics and Genomics
Protease inhibitors
Proteins
Receptors
Thrombin
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Summary:Despite many years of intensive investigation, real biological role of SERPINB2 is largely unknown. However, recent high throughput studies suggest its function in inflammation, influence on autoimmune disorders, and modulation of processes leading to carcinogenesis. SERPINB2 expression is acutely upregulated by many different stimuli, among others by aryl hydrocarbon receptor ligands. Mechanisms of regulation of SERPINB2 expression, involvement of the gene in processes leading to inflammation or carcinogenesis, and its interplay with aryl hydrocarbon receptor are subject of present review.
ISSN:1234-1983
2190-3883
DOI:10.1007/s13353-020-00606-z