Influence of lifestyle choices on risks of CYP 1B1 polymorphisms for prostate cancer

Cytochrome P450 1B1 (CYP1B1) converts xenobiotics to carcinogens and how lifestyle choices may interact with CYP1B1 polymorphisms and affect prostate cancer risk was assessed. Blood genomic DNA from a Caucasian population was analysed at polymorphic sites of the 5′ untranslated region of CYP1B1 usin...

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Bibliographic Details
Published in:Journal of cellular and molecular medicine 2018-10, Vol.22 (10), p.4676-4687
Main Authors: Kato, Taku, Hashimoto, Yutaka, Wong, Ryan K, Mitsui, Yozo, Maekawa, Shigekatsu, Chang, Inik, Varahram Shahryari, Yamamura, Soichiro, Majid, Shahana, Saini, Sharanjot, Tabatabai, Z Laura, Dahiya, Rajvir, Deguchi, Takashi, Tanaka, Yuichiro
Format: Article
Language:English
Subjects:
5' Untranslated Regions
Age
Alcohol
Alcohol use
Alcohols
Alleles
Carcinogens
Cytochrome P450
Deoxyribonucleic acid
DNA
Electrophoretic mobility
Enzymes
Ethanol
Genomics
Genotypes
Genotyping
Haplotypes
Health risk assessment
Health risks
Immunohistochemistry
Lifestyles
Mortality
Patients
Prostate cancer
Smoking
Xenobiotics
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Summary:Cytochrome P450 1B1 (CYP1B1) converts xenobiotics to carcinogens and how lifestyle choices may interact with CYP1B1 polymorphisms and affect prostate cancer risk was assessed. Blood genomic DNA from a Caucasian population was analysed at polymorphic sites of the 5′ untranslated region of CYP1B1 using TaqMan genotyping assays. Overall, drinker status and minor alleles at rs2551188, rs2567206 and rs10175368 were associated with prostate cancer. Linkage was observed between rs2551188, rs2567206, rs2567207 and rs10175368, and the G‐C‐T‐G haplotype (major allele at respective sites) was decreased in cancer. Interestingly when classified by lifestyle factors, no associations of genotypes were found for non‐smokers and non‐drinkers, whereas on the contrary, minor type at rs2567206 and rs10175368 increased and major G‐C‐T‐G decreased risk for cancer among smokers and drinkers. Interestingly, rs2551188, rs2567206 and rs10175368 minor genotypes correlated with increased tissue CYP1B1 as determined by immunohistochemistry. Further, rs10175368 enhanced luciferase activity and mobility shift show stronger binding of nuclear factor for the minor allele. These results demonstrate smoking and alcohol consumption to modify the risks of CYP1B1 polymorphisms for prostate cancer which may be through rs10175368, and this is of importance in understanding their role in the pathogenesis and as a biomarker for this disease.
ISSN:1582-1838
1582-4934
DOI:10.1111/jcmm.13696