Four Mechanistic Mysteries: The Benefits of Writing a Critical Review

While writing a comprehensive review on the reactions of epoxides with titanium(III) reagents, we encountered a series of mechanistic puzzles. Using clues from the literature, many of which were not available at the time that the mysteries emerged, it was possible to demystify a number of these conu...

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Bibliographic Details
Published in:Angewandte Chemie 2021-02, Vol.133 (5), p.2222-2229
Main Authors: Nugent, William A., RajanBabu, T. V.
Format: Article
Language:English
Subjects:
Chemistry
Epoxides
free radicals
organic synthesis
reaction mechanisms
Reagents
Reviews
Titanium
titanium(III) reagents
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Summary:While writing a comprehensive review on the reactions of epoxides with titanium(III) reagents, we encountered a series of mechanistic puzzles. Using clues from the literature, many of which were not available at the time that the mysteries emerged, it was possible to demystify a number of these conundrums. We discuss four examples, which we believe will significantly change the way in which titanium(III) chemistry is practiced. Our experience underscores the importance of comprehensive and critical reviews in chemistry and the truism that the authors are prime beneficiaries of the review process. Clues from the recent literature have been used to unravel a series of mechanistic puzzles regarding the reactions of epoxides with titanium(III) reagents. Four examples are highlighted that will change the way in which titanium(III) chemistry is practiced.
ISSN:0044-8249
1521-3757
DOI:10.1002/ange.202011838