Loading…
A "turn-on" fluorescent sensor for cytosine in aqueous media based on diamino-bridged biphenyl acrylonitrile
The detection of cytosine is of significance for analyzing DNA bases, but no "turn-on" fluorescent sensor for cytosine in aqueous media has been reported so far. In this study, series of diamino-bridged biphenyl acrylonitriles 3a-3c were designed and synthesized with yields of 70-75%. The...
Saved in:
Published in: | New journal of chemistry 2021-01, Vol.45 (3), p.1373-138 |
---|---|
Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | The detection of cytosine is of significance for analyzing DNA bases, but no "turn-on" fluorescent sensor for cytosine in aqueous media has been reported so far. In this study, series of diamino-bridged biphenyl acrylonitriles
3a-3c
were designed and synthesized with yields of 70-75%. The sensing experiments for 16 types of ions and biomolecules suggested that compound
3b
with butanediamino bridges exhibited good selective sensing abilities towards cytosine based on "turn-on" fluorescence enhancement. The detection limit of compound
3b
for cytosine attained 1.02 × 10
−7
M. The selective sensing ability towards cytosine was little influenced by other species and remained stable between pH = 6-9. The sensing mechanism was proposed by the analysis of Job's plot,
1
H NMR and MS binding spectra. The sensing ability for cytosine was successfully used for analysing urine samples with the recovery over 94%. Sample
3b
also exhibited good bioimaging performance with bright blue-green fluorescence for sensing cytosine, implying the application prospect in complicated and living environment.
A "turn-on" fluorescent sensor for cytosine in aqueous media was prepared. |
---|---|
ISSN: | 1144-0546 1369-9261 |
DOI: | 10.1039/d0nj05098a |