Microbial and host‐derived biomarker changes during ligature‐induced and spontaneous peri‐implantitis in the Beagle dog

Objective To evaluate microbial and host‐derived biomarker changes during experimental peri‐implantitis in the Beagle dog. Background Limited data exist on the microbial and biomarker changes during progressive bone loss as result of experimental peri‐implantitis. Methods In total, 36 implants (ndog...

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Bibliographic Details
Published in:Journal of periodontal research 2021-01, Vol.56 (1), p.93-100
Main Authors: Monje, Alberto, Eick, Sigrun, Buser, Daniel, Salvi, Giovanni E.
Format: Article
Language:English
Subjects:
Animals
Bacteria
Bacterial Load
biomarker
Biomarkers
Bone loss
dental implant
Dental implants
Dental Implants - adverse effects
Dogs
endosseous implant
fusobacterium nucleatum
Peri-Implantitis
Statistical analysis
Tannerella forsythia
Transplants & implants
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Summary:Objective To evaluate microbial and host‐derived biomarker changes during experimental peri‐implantitis in the Beagle dog. Background Limited data exist on the microbial and biomarker changes during progressive bone loss as result of experimental peri‐implantitis. Methods In total, 36 implants (ndogs = 6) were assessed over 3 episodes of ligature‐induced peri‐implantitis followed by a period of spontaneous progression. Implants with hybrid (H) and completely rough (R) surface designs were used. Clinical and radiographic parameters were recorded at 4 timepoints. Peri‐implant sulcus fluid was collected from the buccal and lingual aspects of the implants. The presence of 7 bacterial species and 2 host‐derived biomarkers was assessed during the study period. Results Total bacterial counts were significantly correlated with marginal bone loss (MBL) (r = .21; P = .009). Further, Phorphyromonas gulae (Pg) and Tannerella forsythia (Tf) were commonly correlated with MBL, suppuration (SUP) and the sulcular bleeding index scores (mSBI) (P 
ISSN:0022-3484
1600-0765
DOI:10.1111/jre.12797