Structural Characteristics of the Thalamocortical System and α-Rhythm in Mentally Healthy Subjects and Schizophrenic Patients

Current knowledge on morphological and functional abnormalities of the thalamocortical system (TCS) in schizophrenia is incomplete and inconsistent. To study the TСS, 23 young male patients with schizophrenia and 30 healthy males were examined using structural MRI, diffusion-weighted MRI, and EEG. S...

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Bibliographic Details
Published in:Human physiology 2020-11, Vol.46 (6), p.627-635
Main Authors: Manyukhina, V. O., Tomyshev, A. S., Kaleda, V. G., Lebedeva, I. S.
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Hemispheric laterality
Human Physiology
Life Sciences
Magnetic resonance imaging
Mental disorders
Prefrontal cortex
Schizophrenia
Substantia grisea
Thalamus
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Summary:Current knowledge on morphological and functional abnormalities of the thalamocortical system (TCS) in schizophrenia is incomplete and inconsistent. To study the TСS, 23 young male patients with schizophrenia and 30 healthy males were examined using structural MRI, diffusion-weighted MRI, and EEG. Structural abnormalities in the anterior and posterior thalamic radiations, multiple fronto-parietal cortical regions, and the thalamus and a decrease in α power in a subband of 11–12.5 Hz were observed in the patients with schizophrenia compared with the healthy controls. A reduced thickness of the gray matter in the medial prefrontal cortex inversely correlated with structural abnormalities of the thalamus and anterior thalamic radiation in right hemisphere. The results provide further evidence that widespread structural abnormalities of the TCS occur in early stages of schizophrenia.
ISSN:0362-1197
1608-3164
DOI:10.1134/S0362119720050084