Micronization of Levofloxacin Using the RESS Method

The antibacterial drug levofloxacin (LF) is micronized by the Rapid Expansion of the Supercritical Solution (RESS) method to obtain microparticles with a high level of bioavailability. Ethanol is used as a cosolvent to increase the solubility of LF in supercritical carbon dioxide. Spherical LF micro...

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Bibliographic Details
Published in:Russian journal of physical chemistry. B 2020-12, Vol.14 (7), p.1225-1228
Main Authors: Antonov, E. N., Krotova, L. I., Mishakov, G. V., Popov, V. K.
Format: Article
Language:English
Subjects:
Antiinfectives and antibacterials
Bioavailability
Carbon dioxide
Chemistry
Chemistry and Materials Science
Ethanol
Microparticles
Physical Chemistry
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Summary:The antibacterial drug levofloxacin (LF) is micronized by the Rapid Expansion of the Supercritical Solution (RESS) method to obtain microparticles with a high level of bioavailability. Ethanol is used as a cosolvent to increase the solubility of LF in supercritical carbon dioxide. Spherical LF microparticles with the characteristic size of
ISSN:1990-7931
1990-7923
DOI:10.1134/S1990793120070210